High-throughput analysis of the steroid profile in placental cell cultures to evaluate endocrine disrupting effects of contaminant exposure.

Cell Culture Techniques Cell Line, Tumor Estrone Female Humans Placenta Pregnancy Tandem Mass Spectrometry / methods
Disinfection byproducts Placental JEG-3 cells Reprotoxicity Sex hormones Steroid profiling Turbulent flow chromatography

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
29 Mar 2022
Historique:
received: 29 11 2021
revised: 28 01 2022
accepted: 06 02 2022
pubmed: 23 2 2022
medline: 15 3 2022
entrez: 22 2 2022
Statut: ppublish

Résumé

Human placental JEG-3 cells conserve a high P450 aromatase activity and are therefore suitable to evaluate how contaminants may interfere with the routes involved in estrogen synthesis during pregnancy. This has been traditionally assessed by measuring aromatase activity through the amount of tritiated water (

Identifiants

DOI: 10.1016/j.chroma.2022.462886 PMID: 35193068
pubmed: 35193068
pii: S0021-9673(22)00084-X
doi: 10.1016/j.chroma.2022.462886
pii:
doi:

Substances chimiques

Estrone 2DI9HA706A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

462886

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Júlia Mestres (J)

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.

Elisabet Pérez-Albaladejo (E)

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.

Cinta Porte (C)

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain. Electronic address: cpvqam@cid.csic.es.

Cristina Postigo (C)

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain. Electronic address: cprqam@cid.csic.esc.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › High-throughput analysis of the steroid...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › High-throughput analysis of the steroid...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestrone › High-throughput analysis of the steroid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › High-throughput analysis of the steroid...
questionsmedicales.fr › Structures de l'embryon › Placenta › High-throughput analysis of the steroid...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › High-throughput analysis of the steroid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › High-throughput analysis of the steroid...