Impact of seasonal RTS,S/AS01
Burkina Faso
Malaria
Mali
Nutrition
RTS,S/AS01E
Seasonal malaria chemoprevention
Journal
Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
08
11
2021
accepted:
06
02
2022
entrez:
23
2
2022
pubmed:
24
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
A recent trial in Burkina Faso and Mali showed that combining seasonal RTS,S/AS01 In Burkina Faso and Mali 5920 children were randomized to receive either SMC alone, RTS,S/AS01 In 2017, compared to SMC alone, the combined intervention reduced the prevalence of wasting by approximately 12% [prevalence ratio (PR) = 0.88 (95% CI 0.75, 1.03)], and approximately 21% in 2018 [PR = 0.79 (95% CI 0.62, 1.01)]. Point estimates were similar for comparisons with RTS,S/AS01 Despite a high burden of malnutrition and malaria in the study populations, and a major reduction in the incidence of malaria in children receiving both interventions, this had only a modest impact on nutritional status. Therefore, other interventions are needed to reduce the high burden of malnutrition in these areas. https://www.clinicaltrials.gov/ct2/show/NCT03143218 , registered 8th May 2017.
Sections du résumé
BACKGROUND
BACKGROUND
A recent trial in Burkina Faso and Mali showed that combining seasonal RTS,S/AS01
METHODS
METHODS
In Burkina Faso and Mali 5920 children were randomized to receive either SMC alone, RTS,S/AS01
RESULTS
RESULTS
In 2017, compared to SMC alone, the combined intervention reduced the prevalence of wasting by approximately 12% [prevalence ratio (PR) = 0.88 (95% CI 0.75, 1.03)], and approximately 21% in 2018 [PR = 0.79 (95% CI 0.62, 1.01)]. Point estimates were similar for comparisons with RTS,S/AS01
CONCLUSIONS
CONCLUSIONS
Despite a high burden of malnutrition and malaria in the study populations, and a major reduction in the incidence of malaria in children receiving both interventions, this had only a modest impact on nutritional status. Therefore, other interventions are needed to reduce the high burden of malnutrition in these areas.
TRIAL REGISTRATION
BACKGROUND
https://www.clinicaltrials.gov/ct2/show/NCT03143218 , registered 8th May 2017.
Identifiants
pubmed: 35193608
doi: 10.1186/s12936-022-04077-x
pii: 10.1186/s12936-022-04077-x
pmc: PMC8864823
doi:
Substances chimiques
Antimalarials
0
Banques de données
ClinicalTrials.gov
['NCT03143218']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
59Subventions
Organisme : Medical Research Council
ID : MR/P006876/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Organisme : United Kingdom Joint Global Health Trials
ID : MR/P006876/1
Organisme : PATH
ID : 18269
Informations de copyright
© 2022. The Author(s).
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