A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
18
05
2021
accepted:
18
01
2022
revised:
22
12
2021
pubmed:
24
2
2022
medline:
26
5
2022
entrez:
23
2
2022
Statut:
ppublish
Résumé
The emerging understanding of gut microbiota as 'metabolic machinery' influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated with both the potential functionality of the gut microbiota and the biological mechanisms thought to be underpinning mental disorders. In this systematic review, we synthesised the current literature investigating differences in gut microbiota composition in people with the major psychiatric disorders, major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ), compared to 'healthy' controls. We also explored gut microbiota composition across disorders in an attempt to elucidate potential commonalities in the microbial signatures associated with these mental disorders. Following the PRISMA guidelines, databases were searched from inception through to December 2021. We identified 44 studies (including a total of 2510 psychiatric cases and 2407 controls) that met inclusion criteria, of which 24 investigated gut microbiota composition in MDD, seven investigated gut microbiota composition in BD, and 15 investigated gut microbiota composition in SZ. Our syntheses provide no strong evidence for a difference in the number or distribution (α-diversity) of bacteria in those with a mental disorder compared to controls. However, studies were relatively consistent in reporting differences in overall community composition (β-diversity) in people with and without mental disorders. Our syntheses also identified specific bacterial taxa commonly associated with mental disorders, including lower levels of bacterial genera that produce short-chain fatty acids (e.g. butyrate), higher levels of lactic acid-producing bacteria, and higher levels of bacteria associated with glutamate and GABA metabolism. We also observed substantial heterogeneity across studies with regards to methodologies and reporting. Further prospective and experimental research using new tools and robust guidelines hold promise for improving our understanding of the role of the gut microbiota in mental and brain health and the development of interventions based on modification of gut microbiota.
Identifiants
pubmed: 35194166
doi: 10.1038/s41380-022-01456-3
pii: 10.1038/s41380-022-01456-3
pmc: PMC9126816
doi:
Types de publication
Journal Article
Review
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1920-1935Informations de copyright
© 2022. The Author(s).
Références
Cussotto S, Sandhu KV, Dinan TG, Cryan JF. The Neuroendocrinology of the Microbiota-Gut-Brain Axis: a behavioural perspective. Front Neuroendocrinol. 2018;51:80–101.
pubmed: 29753796
doi: 10.1016/j.yfrne.2018.04.002
Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017;20:145–55.
pubmed: 28092661
pmcid: 6960010
doi: 10.1038/nn.4476
Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. Minireview: Gut microbiota: the neglected endocrine organ. Mol Endocrinol. 2014;28:1221–38.
pubmed: 24892638
pmcid: 5414803
doi: 10.1210/me.2014-1108
Evans JM, Morris LS, Marchesi JR. The gut microbiome: the role of a virtual organ in the endocrinology of the host. J Endocrinol. 2013;218:R37–47.
pubmed: 23833275
doi: 10.1530/JOE-13-0131
Luczynski P, McVey Neufeld KA, Oriach CS, Clarke G, Dinan TG, Cryan JF. Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior. Int J Neuropsychopharmacol. 2016;19:pyw020.
pubmed: 26912607
pmcid: 5006193
doi: 10.1093/ijnp/pyw020
Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99:1877–2013.
pubmed: 31460832
doi: 10.1152/physrev.00018.2018
Goldstein AM, Hofstra RM, Burns AJ. Building a brain in the gut: development of the enteric nervous system. Clin Genet. 2013;83:307–16.
pubmed: 23167617
doi: 10.1111/cge.12054
Schneider S, Wright CM, Heuckeroth RO. Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function. Annu Rev Physiol. 2019;81:235–59.
pubmed: 30379617
doi: 10.1146/annurev-physiol-021317-121515
Dipnall JF, Pasco JA, Berk M, Williams LJ, Dodd S, Jacka FN, et al. Into the Bowels of Depression: Unravelling Medical Symptoms Associated with Depression by Applying Machine-Learning Techniques to a Community Based Population Sample. PLoS ONE. 2016;11:e0167055.
pubmed: 27935995
pmcid: 5147841
doi: 10.1371/journal.pone.0167055
Van Oudenhove L, Crowell MD, Drossman DA, Halpert AD, Keefer L, Lackner JM, et al. Biopsychosocial Aspects of Functional Gastrointestinal Disorders. Gastroenterology. 2016;150:1355–67.
doi: 10.1053/j.gastro.2016.02.027
Ford AC, Lacy BE, Harris LA, Quigley EMM, Moayyedi P. Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis. Am J Gastroenterol. 2019;114:21–39.
pubmed: 30177784
doi: 10.1038/s41395-018-0222-5
Sotelo JL, Nemeroff CB. Depression as a systemic disease. Personalized Med Psychiatry. 2017;1–2:11–25.
doi: 10.1016/j.pmip.2016.11.002
Strain JJ, Blumenfield M. Depression As a Systemic Illness. New York: Oxford University Press; 2018.
doi: 10.1093/med/9780190603342.001.0001
Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;381:1371–9.
pmcid: 3714010
doi: 10.1016/S0140-6736(12)62129-1
Khandaker GM, Cousins L, Deakin J, Lennox BR, Yolken R, Jones PB. Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. Lancet Psychiat. 2015;2:258–70.
doi: 10.1016/S2215-0366(14)00122-9
Kiecolt-Glaser JK, Derry HM, Fagundes CP. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry. 2015;172:1075–91.
pubmed: 26357876
pmcid: 6511978
doi: 10.1176/appi.ajp.2015.15020152
Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008;11:851–76.
pubmed: 18205981
doi: 10.1017/S1461145707008401
Myint AM. Kynurenines: from the perspective of major psychiatric disorders. FEBS J. 2012;279:1375–85.
pubmed: 22404766
doi: 10.1111/j.1742-4658.2012.08551.x
Marx W, McGuinness AJ, Rocks T, Ruusunen A, Cleminson J, Walker AJ, et al. The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies. Mol Psychiatry. 2020;8:4158–78.
Jou SH, Chiu NY, Liu CS. Mitochondrial dysfunction and psychiatric disorders. Chang Gung Med J. 2009;32:370–9.
pubmed: 19664343
Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, et al. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Mol Psychiatry. 2017;22:666–79.
pubmed: 28289283
pmcid: 5401767
doi: 10.1038/mp.2017.16
Delgado PL. Depression: the case for a monoamine deficiency. J Clin Psychiatry. 2000;61:7–11.
pubmed: 10775018
Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III-the final common pathway. Schizophr Bull. 2009;35:549–62.
pubmed: 19325164
pmcid: 2669582
doi: 10.1093/schbul/sbp006
Mann JJ. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacol. 1999;21:99S–105S.
doi: 10.1016/S0893-133X(99)00040-8
Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatr Dis Treat. 2011;7:9–13.
pubmed: 21750623
pmcid: 3131098
Autry AE, Monteggia LM. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharm Rev. 2012;64:238–58.
pubmed: 22407616
pmcid: 3310485
doi: 10.1124/pr.111.005108
Firth J, Siddiqi N, Koyanagi A, Siskind D, Rosenbaum S, Galletly C, et al. The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. Lancet Psychiat. 2019;6:675–712.
doi: 10.1016/S2215-0366(19)30132-4
Penninx B, Lange SMM. Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications. Dialogues Clin Neurosci. 2018;20:63–73.
pubmed: 29946213
pmcid: 6016046
doi: 10.31887/DCNS.2018.20.1/bpenninx
Heintz-Buschart A, Wilmes P. Human gut microbiome: function matters. Trends Microbiol. 2018;26:563–74.
pubmed: 29173869
doi: 10.1016/j.tim.2017.11.002
Tanca A, Abbondio M, Palomba A, Fraumene C, Manghina V, Cucca F, et al. Potential and active functions in the gut microbiota of a healthy human cohort. Microbiome. 2017;5:79.
pubmed: 28709472
pmcid: 5513205
doi: 10.1186/s40168-017-0293-3
Bolte LA, Vich Vila A, Imhann F, Collij V, Gacesa R, Peters V, et al. Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut. 2021;70:1287–98.
pubmed: 33811041
doi: 10.1136/gutjnl-2020-322670
Jacka FN, O’Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, et al. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial). BMC Med. 2017;15:23.
pubmed: 28137247
pmcid: 5282719
doi: 10.1186/s12916-017-0791-y
Marx W, Lane M, Hockey M, Aslam H, Berk M, Walder K, et al. Diet and depression: exploring the biological mechanisms of action. Mol Psychiatry. 2020;26:134–50.
pubmed: 33144709
doi: 10.1038/s41380-020-00925-x
Aslam H, Green J, Jacka FN, Collier F, Berk M, Pasco J, et al. Fermented foods, the gut and mental health: a mechanistic overview with implications for depression and anxiety. Nutr Neurosci. 2020;23:659–71.
pubmed: 30415609
doi: 10.1080/1028415X.2018.1544332
Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A, et al. A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: a randomized controlled trial (HELFIMED). Nutr Neurosci. 2019;22:474–87.
pubmed: 29215971
doi: 10.1080/1028415X.2017.1411320
Essali N, Miller BJ. Psychosis as an adverse effect of antibiotics. Brain Behav Immun Health. 2020;9:100148.
pubmed: 34589893
pmcid: 8474525
doi: 10.1016/j.bbih.2020.100148
Hao WZ, Li XJ, Zhang PW, Chen JX. A review of antibiotics, depression, and the gut microbiome. Psychiatry Res. 2020;284:112691.
pubmed: 31791704
doi: 10.1016/j.psychres.2019.112691
Klein-Petersen AW, Kohler-Forsberg O, Benros ME. Infections, antibiotic treatment and the Microbiome in relation to schizophrenia. Schizophr Res. 2021;234:71–7.
pubmed: 31859119
doi: 10.1016/j.schres.2019.11.033
Lambrichts S, Van Oudenhove L, Sienaert P. Antibiotics and mania: a systematic review. J Affect Disord. 2017;219:149–56.
pubmed: 28550767
doi: 10.1016/j.jad.2017.05.029
Lavebratt C, Yang LL, Giacobini M, Forsell Y, Schalling M, Partonen T, et al. Early exposure to antibiotic drugs and risk for psychiatric disorders: a population-based study. Transl Psychiatry. 2019;9:317.
pubmed: 31772217
pmcid: 6879739
doi: 10.1038/s41398-019-0653-9
Lurie I, Yang YX, Haynes K, Mamtani R, Boursi B. Antibiotic exposure and the risk for depression, anxiety, or psychosis: a nested case-control study. J Clin Psychiatry. 2015;76:1522–8.
pubmed: 26580313
doi: 10.4088/JCP.15m09961
Murphy JR, Paul S, Dunlop AL, Corwin EJ. Maternal peripartum antibiotic exposure and the risk of postpartum depression. Res Nurs Health. 2018;41:369–77.
doi: 10.1002/nur.21881
Chao L, Liu C, Sutthawongwadee S, Li Y, Lv W, Chen W, et al. Effects of Probiotics on Depressive or Anxiety Variables in Healthy Participants Under Stress Conditions or With a Depressive or Anxiety Diagnosis: a Meta-Analysis of Randomized Controlled Trials. Front Neurol. 2020;11:421.
pubmed: 32528399
pmcid: 7257376
doi: 10.3389/fneur.2020.00421
Dickerson FB, Stallings C, Origoni A, Katsafanas E, Savage CL, Schweinfurth LA, et al. Effect of probiotic supplementation on schizophrenia symptoms and association with gastrointestinal functioning: a randomized, placebo-controlled trial. Prim Care Companion CNS Disord. 2014;16:PCC.13m01579.
pubmed: 24940526
pmcid: 4048142
Eslami Shahrbabaki M, Sabouri S, Sabahi A, Barfeh D, Divsalar P, Esmailzadeh M, et al. The Efficacy of Probiotics for Treatment of Bipolar Disorder-Type 1: a Randomized, Double-Blind, Placebo Controlled Trial. Iran J Psychiatry. 2020;15:10–6.
pubmed: 32377210
pmcid: 7193240
Ng QX, Soh AYS, Venkatanarayanan N, Ho CYX, Lim DY, Yeo WS. A Systematic Review of the Effect of Probiotic Supplementation on Schizophrenia Symptoms. Neuropsychobiology. 2019;78:1–6.
pubmed: 30947230
doi: 10.1159/000498862
Severance EG, Gressitt KL, Stallings CR, Katsafanas E, Schweinfurth LA, Savage CLG, et al. Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study. Brain Behav Immun. 2017;62:41–5.
pubmed: 27871802
doi: 10.1016/j.bbi.2016.11.019
Tomasik J, Yolken RH, Bahn S, Dickerson FB. Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: a Randomized, Placebo-Controlled Trial. Biomark Insights. 2015;10:47–54.
pubmed: 26052224
pmcid: 4454091
doi: 10.4137/BMI.S22007
Ghaderi A, Banafshe HR, Mirhosseini N, Moradi M, Karimi MA, Mehrzad F, et al. Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients. BMC Psychiatry. 2019;19:77.
pubmed: 30791895
pmcid: 6383260
doi: 10.1186/s12888-019-2059-x
Green J, Castle D, Berk M, Hair C, Loughman A, Cryan J, et al. Faecal microbiota transplants for depression - Who gives a crapsule? Aust N Z J Psychiatry. 2019;53:732–4.
pubmed: 30957511
doi: 10.1177/0004867419839776
Green JE, Davis JA, Berk M, Hair C, Loughman A, Castle D, et al. Efficacy and safety of fecal microbiota transplantation for the treatment of diseases other than Clostridium difficile infection: a systematic review and meta-analysis. Gut Microbes. 2020;12:1–25.
pubmed: 33345703
doi: 10.1080/19490976.2020.1854640
Green JE, Berk M, Loughman A, Marx W, Castle D, McGuinness AJ, et al. FMT for psychiatric disorders: following the brown brick road into the future. Bipolar Disord. 2021;23:651–5.
pubmed: 34841639
doi: 10.1111/bdi.13124
Barandouzi ZA, Starkweather AR, Henderson WA, Gyamfi A, Cong XS. Altered Composition of Gut Microbiota in Depression: a Systematic Review. Front Psychiatry. 2020;11:541.
pubmed: 32587537
pmcid: 7299157
doi: 10.3389/fpsyt.2020.00541
Cheung SG, Goldenthal AR, Uhlemann AC, Mann JJ, Miller JM, Sublette ME. Systematic Review of Gut Microbiota and Major Depression. Front Psychiatry. 2019;10:34.
pubmed: 30804820
pmcid: 6378305
doi: 10.3389/fpsyt.2019.00034
Sanada K, Nakajima S, Kurokawa S, Barcelo-Soler A, Ikuse D, Hirata A, et al. Gut microbiota and major depressive disorder: a systematic review and meta-analysis. J Affect Disord. 2020;266:1–13.
pubmed: 32056863
doi: 10.1016/j.jad.2020.01.102
Simpson CA, Diaz-Arteche C, Eliby D, Schwartz OS, Simmons JG, Cowan CSM. The gut microbiota in anxiety and depression - A systematic review. Clin Psychol Rev. 2021;83:101943.
pubmed: 33271426
doi: 10.1016/j.cpr.2020.101943
Knudsen JK, Bundgaard-Nielsen C, Hjerrild S, Nielsen RE, Leutscher P, Sorensen S. Gut microbiota variations in patients diagnosed with major depressive disorder-A systematic review. Brain Behav. 2021;11:e02177.
pubmed: 34047485
pmcid: 8323045
doi: 10.1002/brb3.2177
Loniewski I, Misera A, Skonieczna-Zydecka K, Kaczmarczyk M, Kazmierczak-Siedlecka K, Misiak B, et al. Major Depressive Disorder and gut microbiota - Association not causation. A scoping review. Prog Neuropsychopharmacol Biol Psychiatry. 2021;106:110111.
pubmed: 32976952
doi: 10.1016/j.pnpbp.2020.110111
Nikolova VL, Smith MRB, Hall LJ, Cleare AJ, Stone JM, Young AH. Perturbations in Gut Microbiota Composition in Psychiatric Disorders: a Review and Meta-analysis. JAMA Psychiatry. 2021;78:1343–54.
pubmed: 34524405
doi: 10.1001/jamapsychiatry.2021.2573
Nguyen TT, Kosciolek T, Eyler LT, Knight R, Jeste DV. Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder. J Psychiatr Res. 2018;99:50–61.
pubmed: 29407287
pmcid: 5849533
doi: 10.1016/j.jpsychires.2018.01.013
Vindegaard N, Speyer H, Nordentoft M, Rasmussen S, Benros ME. Gut microbial changes of patients with psychotic and affective disorders: a systematic review. Schizophr Res. 2020;234:1–10.
pubmed: 31952911
Nguyen TT, Hathaway H, Kosciolek T, Knight R, Jeste DV. Gut microbiome in serious mental illnesses: a systematic review and critical evaluation. Schizophr Res. 2021;234:24–40.
pubmed: 31495702
doi: 10.1016/j.schres.2019.08.026
Sublette ME, Cheung S, Lieberman E, Hu S, Mann JJ, Uhlemann AC, et al. Bipolar Disorder and the Gut Microbiome: a Systematic Review. Bipolar Disord. 2021;23:544–64.
pubmed: 33512753
doi: 10.1111/bdi.13049
Radua J. PRISMA 2020 - An updated checklist for systematic reviews and meta-analyses. Neurosci Biobehav Rev. 2021;124:324–5.
pubmed: 33596413
doi: 10.1016/j.neubiorev.2021.02.016
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5:210.
pubmed: 27919275
pmcid: 5139140
doi: 10.1186/s13643-016-0384-4
Hagerty SL, Hutchison KE, Lowry CA, Bryan AD. An empirically derived method for measuring human gut microbiome alpha diversity: Demonstrated utility in predicting health-related outcomes among a human clinical sample. PLoS ONE. 2020;15:e0229204.
pubmed: 32119675
pmcid: 7051054
doi: 10.1371/journal.pone.0229204
Calle ML. Statistical Analysis of Metagenomics Data. Genomics Inf. 2019;17:e6.
doi: 10.5808/GI.2019.17.1.e6
National Institutes of Health. Quality assessment tool for observational cohort and cross-sectional studies [Internet]. Bethesda (MD): American [cited 2021 May 18]. Available from: https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools . 2014.
Chen JJ, He S, Fang L, Wang B, Bai SJ, Xie J, et al. Age-specific differential changes on gut microbiota composition in patients with major depressive disorder. Aging. 2020;12:2764–76.
pubmed: 32040443
pmcid: 7041727
doi: 10.18632/aging.102775
Chen JJ, Zheng P, Liu YY, Zhong XG, Wang HY, Guo YJ, et al. Sex differences in gut microbiota in patients with major depressive disorder. Neuropsych Dis Treat. 2018;14:647–55.
doi: 10.2147/NDT.S159322
Chung YE, Chen HC, Chou HL, Chen IM, Lee MS, Chuang LC, et al. Exploration of microbiota targets for major depressive disorder and mood related traits. J Psychiatr Res. 2019;111:74–82.
pubmed: 30685565
doi: 10.1016/j.jpsychires.2019.01.016
Huang Y, Shi X, Li Z, Shen Y, Shi X, Wang L, et al. Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder. Neuropsychiatr Dis Treat. 2018;14:3329–37.
pubmed: 30584306
pmcid: 6284853
doi: 10.2147/NDT.S188340
Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 2015;48:186–94.
doi: 10.1016/j.bbi.2015.03.016
Kelly JR, Borre Y, Patterson ECOB, El Aidy S, Deane J, et al. Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res. 2016;82:109–18.
pubmed: 27491067
doi: 10.1016/j.jpsychires.2016.07.019
Lai WT, Deng WF, Xu SX, Zhao J, Xu D, Liu YH et al. Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients. Psychol Med. Epub 2019; Nov 5.
Lin P, Ding B, Feng C, Yin S, Zhang T, Qi X, et al. Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder. J Affect Disord. 2017;207:300–4.
pubmed: 27741466
doi: 10.1016/j.jad.2016.09.051
Liu RT, Rowan-Nash AD, Sheehan AE, Walsh RFL, Sanzari CM, Korry BJ, et al. Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults. Brain Behav Immun. 2020;88:308–24.
pubmed: 32229219
pmcid: 7415740
doi: 10.1016/j.bbi.2020.03.026
Liu Y, Zhang L, Wang X, Wang Z, Zhang J, Jiang R, et al. Similar Fecal Microbiota Signatures in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Patients With Depression. Clin Gastroenterol Hepatol. 2016;14:1602–11 e1605.
pubmed: 27266978
doi: 10.1016/j.cgh.2016.05.033
Mason BL, Li Q, Minhajuddin A, Czysz AH, Coughlin LA, Hussain SK, et al. Reduced anti-inflammatory gut microbiota are associated with depression and anhedonia. J Affect Disord. 2020;266:394–401.
pubmed: 32056905
doi: 10.1016/j.jad.2020.01.137
Naseribafrouei A, Hestad K, Avershina E, Sekelja M, Linløkken A, Wilson R, et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil. 2014;26:1155–62.
pubmed: 24888394
doi: 10.1111/nmo.12378
Rong H, Xie XH, Zhao J, Lai WT, Wang MB, Xu D, et al. Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients. J Psychiatr Res. 2019;113:90–9.
pubmed: 30927646
doi: 10.1016/j.jpsychires.2019.03.017
Stevens BR, Roesch L, Thiago P, Russell JT, Pepine CJ, Holbert RC, et al. Depression phenotype identified by using single nucleotide exact amplicon sequence variants of the human gut microbiome. Mol Psychiatr. 2021;26:4277–87.
doi: 10.1038/s41380-020-0652-5
Zheng P, Yang J, Li Y, Wu J, Liang W, Yin B, et al. Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression. Adv Sci. 2020;7:1902862.
doi: 10.1002/advs.201902862
Zheng P, Zeng B, Zhou C, Liu M, Fang Z, Xu X, et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Mol Psychiatry. 2016;21:786–96.
pubmed: 27067014
doi: 10.1038/mp.2016.44
Chen YH, Xue F, Yu SF, Li XS, Liu L, Jia YY, et al. Gut microbiota dysbiosis in depressed women: the association of symptom severity and microbiota function. J Affect Disord. 2020;282:391–400.
pubmed: 33421868
doi: 10.1016/j.jad.2020.12.143
Yang J, Zheng P, Li Y, Wu J, Tan X, Zhou J, et al. Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders. Sci Adv. 2020;6:eaba8555.
pubmed: 33268363
pmcid: 7710361
doi: 10.1126/sciadv.aba8555
Bai S, Xie J, Bai H, Tian T, Zou T, Chen JJ. Gut Microbiota-Derived Inflammation-Related Serum Metabolites as Potential Biomarkers for Major Depressive Disorder. J Inflamm Res. 2021;14:3755–66.
pubmed: 34393496
pmcid: 8354734
doi: 10.2147/JIR.S324922
Dong Z, Shen X, Hao Y, Li J, Li H, Xu H, et al. Gut Microbiome: a Potential Indicator for Differential Diagnosis of Major Depressive Disorder and General Anxiety Disorder. Front Psychiatry. 2021;12:651536.
pubmed: 34589003
pmcid: 8473618
doi: 10.3389/fpsyt.2021.651536
Shen Y, Yang X, Li G, Gao J, Liang Y. The change of gut microbiota in MDD patients under SSRIs treatment. Sci Rep. 2021;11:14918.
pubmed: 34290352
pmcid: 8295378
doi: 10.1038/s41598-021-94481-1
Ye X, Wang D, Zhu H, Wang D, Li J, Tang Y, et al. Gut Microbiota Changes in Patients With Major Depressive Disorder Treated With Vortioxetine. Front Psychiatry. 2021;12:641491.
pubmed: 34025474
pmcid: 8138160
doi: 10.3389/fpsyt.2021.641491
Zhang Q, Yun Y, An H, Zhao W, Ma T, Wang Z, et al. Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality. Front Psychiatry. 2021;12:645045.
pubmed: 34093266
pmcid: 8175648
doi: 10.3389/fpsyt.2021.645045
Zheng S, Zhu Y, Wu W, Zhang Q, Wang Y, Wang Z, et al. A correlation study of intestinal microflora and first-episode depression in Chinese patients and healthy volunteers. Brain Behav. 2021;11:e02036.
pubmed: 33960717
pmcid: 8413750
doi: 10.1002/brb3.2036
Coello K, Hansen TH, Sørensen N, Munkholm K, Kessing LV, Pedersen O, et al. Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives. Brain Behav Immun. 2019;75:112–8.
pubmed: 30261302
doi: 10.1016/j.bbi.2018.09.026
Evans SJ, Bassis CM, Hein R, Assari S, Flowers SA, Kelly MB, et al. The gut microbiome composition associates with bipolar disorder and illness severity. J Psychiatr Res. 2017;87:23–9.
pubmed: 27988330
doi: 10.1016/j.jpsychires.2016.12.007
Hu S, Li A, Huang T, Lai J, Li J, Sublette ME, et al. Gut Microbiota Changes in Patients with Bipolar Depression. Adv Sci. 2019;6:1900752.
doi: 10.1002/advs.201900752
McIntyre RS, Subramaniapillai M, Shekotikhina M, Carmona NE, Lee Y, Mansur RB et al. Characterizing the gut microbiota in adults with bipolar disorder: a pilot study. Nutr Neurosci. Epub 2019; May 28.
Lai WT, Zhao J, Xu SX, Deng WF, Xu D, Wang MB, et al. Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in bipolar disorder with current major depressive episode patients. J Affect Disord. 2021;278:311–9.
pubmed: 32979562
doi: 10.1016/j.jad.2020.09.010
Li S, Zhuo M, Huang X, Huang Y, Zhou J, Xiong D, et al. Altered gut microbiota associated with symptom severity in schizophrenia. PeerJ. 2020;8:e9574.
pubmed: 32821537
pmcid: 7395597
doi: 10.7717/peerj.9574
Ma X, Asif H, Dai L, He Y, Zheng W, Wang D, et al. Alteration of the gut microbiome in first-episode drug-naïve and chronic medicated schizophrenia correlate with regional brain volumes. J Psychiatr Res. 2020;123:136–44.
pubmed: 32065949
doi: 10.1016/j.jpsychires.2020.02.005
Nguyen TT, Kosciolek T, Maldonado Y, Daly RE, Martin AS, McDonald D, et al. Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects. Schizophr Res. 2019;204:23–9.
pubmed: 30268819
doi: 10.1016/j.schres.2018.09.014
Pan R, Zhang X, Gao J, Yi W, Wei Q, Su H. Analysis of the diversity of intestinal microbiome and its potential value as a biomarker in patients with schizophrenia: a cohort study. Psychiatry Res. 2020;291:113260.
pubmed: 32763534
doi: 10.1016/j.psychres.2020.113260
Shen Y, Xu J, Li Z, Huang Y, Yuan Y, Wang J, et al. Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: a cross-sectional study. Schizophr Res. 2018;197:470–7.
pubmed: 29352709
doi: 10.1016/j.schres.2018.01.002
Xu R, Wu B, Liang J, He F, Gu W, Li K, et al. Altered gut microbiota and mucosal immunity in patients with schizophrenia. Brain Behav Immun. 2020;85:120–7.
pubmed: 31255682
doi: 10.1016/j.bbi.2019.06.039
Zhang X, Pan L-Y, Zhang Z, Zhou Y-Y, Jiang H-Y, Ruan B. Analysis of gut mycobiota in first-episode, drug-naïve Chinese patients with schizophrenia: a pilot study. Behav Brain Res. 2019;379:112374.
pubmed: 31759045
doi: 10.1016/j.bbr.2019.112374
Zheng P, Zeng B, Liu M, Chen J, Pan J, Han Y, et al. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. Sci Adv. 2019;5:eaau8317.
pubmed: 30775438
pmcid: 6365110
doi: 10.1126/sciadv.aau8317
Zhu F, Ju Y, Wang W, Wang Q, Guo R, Ma Q, et al. Metagenome-wide association of gut microbiome features for schizophrenia. Nat Commun. 2020;11:1612.
pubmed: 32235826
pmcid: 7109134
doi: 10.1038/s41467-020-15457-9
Nguyen TT, Kosciolek T, Daly RE, Vazquez-Baeza Y, Swafford A, Knight R, et al. Gut microbiome in Schizophrenia: altered functional pathways related to immune modulation and atherosclerotic risk. Brain Behav Immun. 2021;91:245–56.
pubmed: 33098964
doi: 10.1016/j.bbi.2020.10.003
Li S, Song J, Ke P, Kong L, Lei B, Zhou J, et al. The gut microbiome is associated with brain structure and function in schizophrenia. Sci Rep. 2021;11:9743.
pubmed: 33963227
pmcid: 8105323
doi: 10.1038/s41598-021-89166-8
Manchia M, Fontana A, Panebianco C, Paribello P, Arzedi C, Cossu E, et al. Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics. Biomedicines. 2021;9:875.
pubmed: 34440078
pmcid: 8389684
doi: 10.3390/biomedicines9080875
Miao Y, Li X, Yuan XX, Zhang LY, Pang LJ, Zhang XY, et al. Effect of the correlation between gut microbiota and folic acid in first-episode schizophrenia. Zhonghua Yi Xue Za Zhi. 2021;101:3012–7.
pubmed: 34638193
Yuan X, Wang Y, Li X, Jiang J, Kang Y, Pang L, et al. Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study. Transl Psychiatry. 2021;11:422.
pubmed: 34376634
pmcid: 8355081
doi: 10.1038/s41398-021-01531-3
Zhu C, Zheng M, Ali U, Xia Q, Wang Z. Chenlong, et al. Association Between Abundance of Haemophilus in the Gut Microbiota and Negative Symptoms of Schizophrenia. Front Psychiatry. 2021;12:685910.
pubmed: 34393849
pmcid: 8362742
doi: 10.3389/fpsyt.2021.685910
Langille MG, Zaneveld J, Caporaso JG, McDonald D, Knights D, Reyes JA, et al. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol. 2013;31:814–21.
pubmed: 23975157
pmcid: 3819121
doi: 10.1038/nbt.2676
Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28:27–30.
pubmed: 10592173
pmcid: 102409
doi: 10.1093/nar/28.1.27
Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol. 2019;4:623–32.
pubmed: 30718848
doi: 10.1038/s41564-018-0337-x
Larsen OFA, Claassen E. The mechanistic link between health and gut microbiota diversity. Sci Rep. 2018;8:2183.
pubmed: 29391457
pmcid: 5794854
doi: 10.1038/s41598-018-20141-6
Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK. Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489:220–30.
pubmed: 22972295
pmcid: 3577372
doi: 10.1038/nature11550
Crovesy L, Masterson D, Rosado EL. Profile of the gut microbiota of adults with obesity: a systematic review. Eur J Clin Nutr. 2020;74:1251–62.
pubmed: 32231226
doi: 10.1038/s41430-020-0607-6
Gurung M, Li Z, You H, Rodrigues R, Jump DB, Morgun A, et al. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 2020;51:102590.
pubmed: 31901868
pmcid: 6948163
doi: 10.1016/j.ebiom.2019.11.051
Pittayanon R, Lau JT, Yuan Y, Leontiadis GI, Tse F, Surette M, et al. Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review. Gastroenterology. 2019;157:97–108.
pubmed: 30940523
doi: 10.1053/j.gastro.2019.03.049
Pittayanon R, Lau JT, Leontiadis GI, Tse F, Yuan Y, Surette M, et al. Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: a systematic review. Gastroenterology. 2020;158:930–46 e931.
pubmed: 31812509
doi: 10.1053/j.gastro.2019.11.294
Nuzum ND, Loughman A, Szymlek-Gay EA, Hendy A, Teo WP, Macpherson H. Gut microbiota differences between healthy older adults and individuals with Parkinson’s disease: a systematic review. Neurosci Biobehav Rev. 2020;112:227–41.
pubmed: 32032654
doi: 10.1016/j.neubiorev.2020.02.003
Mirza A, Forbes JD, Zhu F, Bernstein CN, Van Domselaar G, Graham M, et al. The multiple sclerosis gut microbiota: a systematic review. Mult Scler Relat Disord. 2020;37:101427.
pubmed: 32172998
doi: 10.1016/j.msard.2019.101427
Ho LKH, Tong VJW, Syn N, Nagarajan N, Tham EH, Tay SK, et al. Gut microbiota changes in children with autism spectrum disorder: a systematic review. Gut Pathog. 2020;12:6.
pubmed: 32025243
pmcid: 6996179
doi: 10.1186/s13099-020-0346-1
Durazzi F, Sala C, Castellani G, Manfreda G, Remondini D, De Cesare A. Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota. Sci Rep. 2021;11:3030.
pubmed: 33542369
pmcid: 7862389
doi: 10.1038/s41598-021-82726-y
Willis AD. Rarefaction, Alpha Diversity, and Statistics. Front Microbiol. 2019;10:2407.
pubmed: 31708888
pmcid: 6819366
doi: 10.3389/fmicb.2019.02407
George F, Daniel C, Thomas M, Singer E, Guilbaud A, Tessier FJ, et al. Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective. Front Microbiol. 2018;9:2899.
pubmed: 30538693
pmcid: 6277688
doi: 10.3389/fmicb.2018.02899
Pessione E. Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows. Front Cell Infect Microbiol. 2012;2:86.
pubmed: 22919677
pmcid: 3417654
doi: 10.3389/fcimb.2012.00086
Duncan SH, Louis P, Flint HJ. Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Appl Environ Microbiol. 2004;70:5810–7.
pubmed: 15466518
pmcid: 522113
doi: 10.1128/AEM.70.10.5810-5817.2004
Pham VT, Lacroix C, Braegger CP, Chassard C. Lactate-utilizing community is associated with gut microbiota dysbiosis in colicky infants. Sci Rep. 2017;7:11176.
pubmed: 28894218
pmcid: 5593888
doi: 10.1038/s41598-017-11509-1
Dogan AE, Yuksel C, Du F, Chouinard VA, Ongur D. Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies. Neuropsychopharmacology. 2018;43:1681–90.
pubmed: 29581538
pmcid: 6006165
doi: 10.1038/s41386-018-0041-9
Regenold WT, Phatak P, Marano CM, Sassan A, Conley RR, Kling MA. Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis. Biol Psychiatry. 2009;65:489–94.
pubmed: 19103439
doi: 10.1016/j.biopsych.2008.11.010
Proia P, Di Liegro CM, Schiera G, Fricano A, Di Liegro I. Lactate as a Metabolite and a Regulator in the Central Nervous System. Int J Mol Sci. 2016;17:1450.
pmcid: 5037729
doi: 10.3390/ijms17091450
Ernst J, Hock A, Henning A, Seifritz E, Boeker H, Grimm S. Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder. Mol Psychiatry. 2017;22:113–9.
pubmed: 27184123
doi: 10.1038/mp.2016.73
Kuang H, Duong A, Jeong H, Zachos K, Andreazza AC. Lactate in bipolar disorder: a systematic review and meta-analysis. Psychiatry Clin Neurosci. 2018;72:546–55.
pubmed: 29726068
doi: 10.1111/pcn.12671
Ng SK, Hamilton IR. Carbon dioxide fixation by Veillonella parvula M 4 and its relation to propionic acid formation. Can J Microbiol. 1973;19:715–23.
pubmed: 4712506
doi: 10.1139/m73-116
Hao C, Gao Z, Liu X, Rong Z, Jia J, Kang K, et al. Intravenous administration of sodium propionate induces antidepressant or prodepressant effect in a dose dependent manner. Sci Rep. 2020;10:19917.
pubmed: 33199803
pmcid: 7670463
doi: 10.1038/s41598-020-77085-z
Killingsworth J, Sawmiller D, Shytle RD. Propionate and Alzheimer’s Disease. Front Aging Neurosci. 2020;12:580001.
pubmed: 33505301
doi: 10.3389/fnagi.2020.580001
Ghanizadeh A, Berk M. Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia. Med Gas Res. 2013;3:11.
pubmed: 23742229
pmcid: 3680337
doi: 10.1186/2045-9912-3-11
Smith NW, Shorten PR, Altermann EH, Roy NC, McNabb WC. Hydrogen cross-feeders of the human gastrointestinal tract. Gut Microbes. 2019;10:270–88.
pubmed: 30563420
doi: 10.1080/19490976.2018.1546522
Dordevic D, Jancikova S, Vitezova M, Kushkevych I. Hydrogen sulfide toxicity in the gut environment: meta-analysis of sulfate-reducing and lactic acid bacteria in inflammatory processes. J Adv Res. 2021;27:55–69.
pubmed: 33318866
doi: 10.1016/j.jare.2020.03.003
Cussotto S, Clarke G, Dinan TG, Cryan JF. Psychotropics and the Microbiome: a Chamber of Secrets. Psychopharmacology. 2019;236:1411–32.
pubmed: 30806744
pmcid: 6598948
doi: 10.1007/s00213-019-5185-8
Manor O, Dai CL, Kornilov SA, Smith B, Price ND, Lovejoy JC, et al. Health and disease markers correlate with gut microbiome composition across thousands of people. Nat Commun. 2020;11:5206.
pubmed: 33060586
pmcid: 7562722
doi: 10.1038/s41467-020-18871-1
Spichak S, Bastiaanssen TFS, Berding K, Vlckova K, Clarke G, Dinan TG, et al. Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease. Neurosci Biobehav Rev. 2021;125:698–761.
pubmed: 33675857
doi: 10.1016/j.neubiorev.2021.02.044
Riviere A, Selak M, Lantin D, Leroy F, De Vuyst L. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Front Microbiol. 2016;7:979.
pubmed: 27446020
pmcid: 4923077
doi: 10.3389/fmicb.2016.00979
Duncan SH, Aminov RI, Scott KP, Louis P, Stanton TB, Flint HJ. Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces. Int J Syst Evol Microbiol. 2006;56:2437–41.
pubmed: 17012576
doi: 10.1099/ijs.0.64098-0
Rios-Covian D, Gueimonde M, Duncan SH, Flint HJ, de los Reyes-Gavilan CG. Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis. FEMS Microbiol Lett. 2015;362:fnv176.
pubmed: 26420851
doi: 10.1093/femsle/fnv176
Stilling RM, van de Wouw M, Clarke G, Stanton C, Dinan TG, Cryan JF. The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis? Neurochem Int. 2016;99:110–32.
pubmed: 27346602
doi: 10.1016/j.neuint.2016.06.011
Parada Venegas D, De la Fuente MK, Landskron G, Gonzalez MJ, Quera R, Dijkstra G, et al. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Front Immunol. 2019;10:277.
pubmed: 30915065
pmcid: 6421268
doi: 10.3389/fimmu.2019.00277
Lasselin J, Lekander M, Benson S, Schedlowski M, Engler H. Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression. Mol Psychiatry. 2021;26:3672–83.
pubmed: 32873895
doi: 10.1038/s41380-020-00869-2
Maes M, Kubera M, Leunis JC, Berk M. Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut. J Affect Disord. 2012;141:55–62.
pubmed: 22410503
doi: 10.1016/j.jad.2012.02.023
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, et al. Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. Gut. 2020;69:1258–68.
pubmed: 32075887
doi: 10.1136/gutjnl-2019-320438
Lyu C, Zhao W, Peng C, Hu S, Fang H, Hua Y, et al. Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and gamma-aminobutyric acid production. Micro Cell Fact. 2018;17:180.
doi: 10.1186/s12934-018-1029-1
Yogeswara IBA, Maneerat S, Haltrich D. Glutamate Decarboxylase from Lactic Acid Bacteria-A Key Enzyme in GABA Synthesis. Microorganisms. 2020;8:1923.
pmcid: 7761890
doi: 10.3390/microorganisms8121923
Wang M, Wan J, Rong H, He F, Wang H, Zhou J, et al. Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder. mSystems. 2019;4:e00321–18.
pubmed: 30701194
pmcid: 6351726
doi: 10.1128/mSystems.00321-18
Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J, et al. GABA-modulating bacteria of the human gut microbiota. Nat Microbiol. 2019;4:396–403.
pubmed: 30531975
doi: 10.1038/s41564-018-0307-3
Videnska P, Smerkova K, Zwinsova B, Popovici V, Micenkova L, Sedlar K, et al. Stool sampling and DNA isolation kits affect DNA quality and bacterial composition following 16S rRNA gene sequencing using MiSeq Illumina platform. Sci Rep. 2019;9:13837.
pubmed: 31554833
pmcid: 6761292
doi: 10.1038/s41598-019-49520-3
Martinez N, Hidalgo-Cantabrana C, Delgado S, Margolles A, Sanchez B. Filling the gap between collection, transport and storage of the human gut microbiota. Sci Rep. 2019;9:8327.
pubmed: 31171823
pmcid: 6554407
doi: 10.1038/s41598-019-44888-8
Siegwald L, Caboche S, Even G, Viscogliosi E, Audebert C, Chabe M. The Impact of Bioinformatics Pipelines on Microbiota Studies: does the Analytical “Microscope” Affect the Biological Interpretation? Microorganisms. 2019;7:393.
pmcid: 6843237
doi: 10.3390/microorganisms7100393
Singh RK, Chang HW, Yan D, Lee KM, Ucmak D, Wong K, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15:73.
pubmed: 28388917
pmcid: 5385025
doi: 10.1186/s12967-017-1175-y
Berding K, Vlckova K, Marx W, Schellekens H, Stanton C, Clarke G, et al. Diet and the Microbiota-Gut-Brain Axis: Sowing the Seeds of Good Mental Health. Adv Nutr. 2021;12:1239–85.
pubmed: 33693453
pmcid: 8321864
doi: 10.1093/advances/nmaa181
Mirzayi C, Renson A, Genomic Standards C, Massive A, Quality Control S, Zohra F, et al. Reporting guidelines for human microbiome research: the STORMS checklist. Nat Med. 2021;27:1885–92.
pubmed: 34789871
pmcid: 9105086
doi: 10.1038/s41591-021-01552-x
Mirzayi C, Renson A, Zohra F, Elsafoury S, Kasselman L, van de Wijgert J et al. Strengthening The Organizing and Reporting of Microbiome Studies (STORMS). bioRxiv. 2020;2020.06.24.167353.
Senghor B, Sokhna C, Ruimy R, Lagier J-C. Gut microbiota diversity according to dietary habits and geographical provenance. Hum Microbiome J. 2018;7-8:1–9.
doi: 10.1016/j.humic.2018.01.001
Jiang HY, Pan LY, Zhang X, Zhang Z, Zhou YY, Ruan B. Altered gut bacterial-fungal interkingdom networks in patients with current depressive episode. Brain Behav. 2020;10:e01677.
pubmed: 32533650
pmcid: 7428472
doi: 10.1002/brb3.1677
Johnson JS, Spakowicz DJ, Hong BY, Petersen LM, Demkowicz P, Chen L, et al. Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis. Nat Commun. 2019;10:5029.
pubmed: 31695033
pmcid: 6834636
doi: 10.1038/s41467-019-13036-1
Poretsky R, Rodriguez RL, Luo C, Tsementzi D, Konstantinidis KT. Strengths and limitations of 16S rRNA gene amplicon sequencing in revealing temporal microbial community dynamics. PLoS ONE. 2014;9:e93827.
pubmed: 24714158
pmcid: 3979728
doi: 10.1371/journal.pone.0093827