Heart-brain interactions in cardiac and brain diseases: why sex matters.
Brain
Dementia
Depression
Gender
Heart
Heart failure
Ischaemic heart disease
Sex
Stroke
Takotsubo syndrome
Journal
European heart journal
ISSN: 1522-9645
Titre abrégé: Eur Heart J
Pays: England
ID NLM: 8006263
Informations de publication
Date de publication:
14 10 2022
14 10 2022
Historique:
received:
01
09
2021
revised:
24
01
2022
accepted:
30
01
2022
pubmed:
24
2
2022
medline:
19
10
2022
entrez:
23
2
2022
Statut:
ppublish
Résumé
Cardiovascular disease and brain disorders, such as depression and cognitive dysfunction, are highly prevalent conditions and are among the leading causes limiting patient's quality of life. A growing body of evidence has shown an intimate crosstalk between the heart and the brain, resulting from a complex network of several physiological and neurohumoral circuits. From a pathophysiological perspective, both organs share common risk factors, such as hypertension, diabetes, smoking or dyslipidaemia, and are similarly affected by systemic inflammation, atherosclerosis, and dysfunction of the neuroendocrine system. In addition, there is an increasing awareness that physiological interactions between the two organs play important roles in potentiating disease and that sex- and gender-related differences modify those interactions between the heart and the brain over the entire lifespan. The present review summarizes contemporary evidence of the effect of sex on heart-brain interactions and how these influence pathogenesis, clinical manifestation, and treatment responses of specific heart and brain diseases.
Identifiants
pubmed: 35194633
pii: 6534632
doi: 10.1093/eurheartj/ehac061
pmc: PMC9794190
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3971-3980Subventions
Organisme : NIAMS NIH HHS
ID : R56 AR077187
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG065141
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152957
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149516
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137913
Pays : United States
Organisme : NHLBI NIH HHS
ID : R33 HL141047
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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