Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
23 02 2022
23 02 2022
Historique:
entrez:
23
2
2022
pubmed:
24
2
2022
medline:
27
4
2022
Statut:
ppublish
Résumé
Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK cell function, expansion, and persistence remain key challenges for optimal clinical translation. One promising strategy to overcome these challenges is cytokine-induced memory-like (ML) differentiation, whereby NK cells acquire enhanced antitumor function after stimulation with interleukin-12 (IL-12), IL-15, and IL-18. Here, reduced-intensity conditioning (RIC) for
Identifiants
pubmed: 35196021
doi: 10.1126/scitranslmed.abm1375
pmc: PMC9210521
mid: NIHMS1809726
doi:
Substances chimiques
Interleukin-15
0
Banques de données
ClinicalTrials.gov
['NCT02782546']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabm1375Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM139799
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA171963
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA205239
Pays : United States
Organisme : NIGMS NIH HHS
ID : F31 GM146361
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
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