Novel

ABCD1 protein, human RAB3GAP1 protein, human Warburg Micro syndrome mutation whole exome sequencing

Journal

Journal of clinical neurology (Seoul, Korea)
ISSN: 1738-6586
Titre abrégé: J Clin Neurol
Pays: Korea (South)
ID NLM: 101252374

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 21 05 2021
revised: 24 08 2021
accepted: 24 08 2021
pubmed: 24 2 2022
medline: 24 2 2022
entrez: 23 2 2022
Statut: ppublish

Résumé

Warburg Micro syndrome (WARBM) is a rare autosomal recessive genetic disease characterized by ocular, neurologic, and endocrine anomalies. WARBM is a phenotypically and genetically heterogeneous syndrome caused by mutations in We applied whole-exome sequencing (WES) to two affected young males presenting a WARBM-compatible phenotype. We reveal a new variation in WES analysis of a consanguineous Tunisian family with WARBM revealed a novel variation in

Sections du résumé

BACKGROUND AND PURPOSE OBJECTIVE
Warburg Micro syndrome (WARBM) is a rare autosomal recessive genetic disease characterized by ocular, neurologic, and endocrine anomalies. WARBM is a phenotypically and genetically heterogeneous syndrome caused by mutations in
METHODS METHODS
We applied whole-exome sequencing (WES) to two affected young males presenting a WARBM-compatible phenotype.
RESULTS RESULTS
We reveal a new variation in
CONCLUSIONS CONCLUSIONS
WES analysis of a consanguineous Tunisian family with WARBM revealed a novel variation in

Identifiants

pubmed: 35196747
doi: 10.3988/jcn.2022.18.2.214
pii: 18.e2
pmc: PMC8926778
doi:

Types de publication

Journal Article

Langues

eng

Pagination

214-222

Informations de copyright

Copyright © 2022 Korean Neurological Association.

Déclaration de conflit d'intérêts

The authors have no potential conflicts of interest to disclose.

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Auteurs

Nesrine Kerkeni (N)

University of Tunis El Manar, Faculty of Medicine of Tunis, Laboratory of Human Genetics LR99ES10, Tunis, Tunisia.

Maher Kharrat (M)

University of Tunis El Manar, Faculty of Medicine of Tunis, Laboratory of Human Genetics LR99ES10, Tunis, Tunisia.

Faouzi Maazoul (F)

University of Tunis El Manar, Faculty of Medicine of Tunis, Laboratory of Human Genetics LR99ES10, Tunis, Tunisia.
Department of Congenital and Hereditary Diseases, Charles Nicolle Hospital, Tunis, Tunisia.

Hela Boudabous (H)

Department of Paediatrics, Rabta Hospital, Tunis, Tunisia.

Ridha M'rad (R)

University of Tunis El Manar, Faculty of Medicine of Tunis, Laboratory of Human Genetics LR99ES10, Tunis, Tunisia.
Department of Congenital and Hereditary Diseases, Charles Nicolle Hospital, Tunis, Tunisia.

Mediha Trabelsi (M)

University of Tunis El Manar, Faculty of Medicine of Tunis, Laboratory of Human Genetics LR99ES10, Tunis, Tunisia.
Department of Congenital and Hereditary Diseases, Charles Nicolle Hospital, Tunis, Tunisia. mediha.trabelsi@fmt.utm.tn.

Classifications MeSH