Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4

Animals Binding Sites CD4-Positive T-Lymphocytes / metabolism Integrins / metabolism Mice Talin / genetics rap1 GTP-Binding Proteins / metabolism

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 03 2022
Historique:
received: 23 08 2021
accepted: 27 12 2021
pubmed: 25 2 2022
medline: 10 5 2022
entrez: 24 2 2022
Statut: ppublish

Résumé

Agonist-induced Rap1 GTP loading results in integrin activation involved in T cell trafficking and functions. MRL proteins Rap1-interacting adapter molecule (RIAM) and lamellipodin (LPD) are Rap1 effectors that can recruit talin1 to integrins, resulting in integrin activation. Recent work also implicates direct Rap1-talin1 interaction in integrin activation. Here, we analyze in mice the connections between Rap1 and talin1 that support integrin activation in conventional CD4

Identifiants

DOI: 10.4049/jimmunol.2100843 PMID: 35197328 PMC: PMC9644409
pubmed: 35197328
pii: jimmunol.2100843
doi: 10.4049/jimmunol.2100843
pmc: PMC9644409
mid: NIHMS1843834
doi:

Substances chimiques

Integrins 0
Talin 0
rap1 GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1378-1388

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL145454
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS121070
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL133530
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL151433
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL145817
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139947
Pays : United States

Informations de copyright

Copyright © 2022 by The American Association of Immunologists, Inc.

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Auteurs

Frederic Lagarrigue (F)

Institut de Pharmacologie et Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, Toulouse, France.
ORCID: 0000-0002-4660-8666

Boyang Tan (B)

Department of Medicine, University of California, San Diego, La Jolla, CA; and.

Qinyi Du (Q)

Department of Medicine, University of California, San Diego, La Jolla, CA; and.

Zhichao Fan (Z)

Department of Immunology, School of Medicine, University of Connecticut, UConn Health, Farmington, CT.
ORCID: 0000-0001-5385-9626

Miguel A Lopez-Ramirez (MA)

Department of Medicine, University of California, San Diego, La Jolla, CA; and.
ORCID: 0000-0001-7089-4060

Alexandre R Gingras (AR)

Department of Medicine, University of California, San Diego, La Jolla, CA; and.
ORCID: 0000-0002-5373-0176

Hsin Wang (H)

Department of Medicine, University of California, San Diego, La Jolla, CA; and.
ORCID: 0000-0001-9707-5436

Weiwei Qi (W)

Department of Medicine, University of California, San Diego, La Jolla, CA; and.

Hao Sun (H)

Department of Medicine, University of California, San Diego, La Jolla, CA; and has073@ucsd.edu.
ORCID: 0000-0002-4790-8847

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Direct Binding of Rap1 to Talin1 and to MRL...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Direct Binding of Rap1 to Talin1 and to MRL...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Direct Binding of Rap1 to Talin1 and to MRL...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Direct Binding of Rap1 to Talin1 and to MRL...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Direct Binding of Rap1 to Talin1 and to MRL...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Taline › Direct Binding of Rap1 to Talin1 and to MRL...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rap › Protéines G rap1 › Direct Binding of Rap1 to Talin1 and to MRL...