Cortical Thickness and Clinical Findings in Prescholar Children With Autism Spectrum Disorder.
MRI
autism spectrum disorder (ASD)
cortical thickness
local gyrification index
neuropsychological
pre-scholar child
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
09
2021
accepted:
16
12
2021
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
The term autism spectrum disorder (ASD) includes a wide variability of clinical presentation, and this clinical heterogeneity seems to reflect a still unclear multifactorial etiopathogenesis, encompassing different genetic risk factors and susceptibility to environmental factors. Several studies and many theories recognize as mechanisms of autism a disruption of brain development and maturation time course, suggesting the existence of common neurobiological substrates, such as defective synaptic structure and aberrant brain connectivity. Magnetic resonance imaging (MRI) plays an important role in both assessment of region-specific structural changes and quantification of specific alterations in gray or white matter, which could lead to the identification of an MRI biomarker. In this study, we performed measurement of cortical thickness in a selected well-known group of preschool ASD subjects with the aim of finding correlation between cortical metrics and clinical scores to understand the underlying mechanism of symptoms and to support early clinical diagnosis. Our results confirm that recent brain MRI techniques combined with clinical data can provide some useful information in defining the cerebral regions involved in ASD although large sample studies with homogeneous analytical and multisite approaches are needed.
Identifiants
pubmed: 35197818
doi: 10.3389/fnins.2021.776860
pmc: PMC8858962
doi:
Types de publication
Journal Article
Langues
eng
Pagination
776860Informations de copyright
Copyright © 2022 Lucibello, Bertè, Verdolotti, Lucignani, Napolitano, D’Abronzo, Cicala, Pede, Chieffo, Mariotti, Colosimo, Mercuri and Battini.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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