Profiling the Bladder Microbiota in Patients With Bladder Cancer.
actinobacteria
bladder
cancer
microbiota
sequencing
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
06
2021
accepted:
22
12
2021
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
Evidence suggests that microbiota may contribute to the pathogenesis of several diseases, including cancer. In the case of bladder cancer, preliminary studies have found alterations in the urinary microbiota of patients with urothelial carcinoma compared with healthy individuals. Conversely, the urinary microbiota differ between men and women, and it has been hypothesized that these differences are associated with the lower incidence of bladder cancers in women. The objective of this study was to characterize the bladder microbiota in paired samples of tumor and non-tumor mucosa of patients with malignant bladder neoplasia using next-generation sequencing. In addition, we aimed to study potential differences in microbial composition in tumor samples according to clinical and pathological variables, and to determine possible microbial profiles. We found significant differences in microbial richness at the genus level, with a higher richness observed in the non-tumor compared with the tumor mucosa. It was also shown that
Identifiants
pubmed: 35197936
doi: 10.3389/fmicb.2021.718776
pmc: PMC8859159
doi:
Types de publication
Journal Article
Langues
eng
Pagination
718776Informations de copyright
Copyright © 2022 Parra-Grande, Oré-Arce, Martínez-Priego, D’Auria, Rosselló-Mora, Lillo, Sempere, Lumbreras and Sánchez-Hellín.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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