Deep Vein Thrombosis in Lepromatous Leprosy: A Case Report of Secondary Pediatric Antiphospholipid Syndrome.
antiphospholipid syndrome
autoimmune
deep vein thrombosis
leprosy
pediatric
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
accepted:
17
01
2022
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by thromboembolic events, fetal loss during pregnancy, and evidence of antiphospholipid (aPL) antibodies such as beta-2-glycoprotein I (B2-GPI) and anticardiolipin (aCL). The diagnosis and treatment of this condition in the pediatric population have limited literature evidence due to the rarity of the condition in this age group. Guidelines have been adopted from the adult counterpart of the affected population, thereby giving rise to diagnostic and therapeutic challenges. In this report, we describe a rare case of a 15-year-old male who presented with lepromatous leprosy and developed deep vein thrombosis in his right leg. The laboratory evidence of positive aPL antibodies guided our diagnosis of APS and treatment with oral anticoagulants. This report highlights the importance of screening and timely diagnosis of APS in the pediatric population presenting with venous thrombosis in the backdrop of infection.
Identifiants
pubmed: 35198275
doi: 10.7759/cureus.21361
pmc: PMC8853942
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e21361Informations de copyright
Copyright © 2022, Jones et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Eur J Rheumatol. 2019 Dec 03;:1-10
pubmed: 31804173
Lupus. 2010 Apr;19(4):428-31
pubmed: 20353982
Arthritis Rheumatol. 2019 Sep;71(9):1545-1552
pubmed: 30957430
Ann Rheum Dis. 2017 Oct;76(10):1637-1641
pubmed: 28473426
Pediatrics. 2008 Nov;122(5):e1100-7
pubmed: 18955411
Lupus. 2000;9(8):594-600
pubmed: 11035434
Best Pract Res Clin Rheumatol. 2020 Feb;34(1):101463
pubmed: 31866276
N Engl J Med. 2013 Mar 14;368(11):1033-44
pubmed: 23484830
Front Pediatr. 2018 Nov 27;6:362
pubmed: 30542645
Blood Rev. 2017 Nov;31(6):406-417
pubmed: 28784423