Contemporary kidney transplantation has a limited impact on bone microarchitecture.
2D, two-dimensional
3D, three-dimensional
BALP, bone-specific alkaline phosphatase
BMD, bone mineral density
Bone density
Bone histomorphometry
CKD, chronic kidney disease
Chronic kidney disease – mineral and bone disorder
DXA, dual-energy x-ray absorptiometry
HRpQCT, high-resolution peripheral quantitative computed tomography
Kidney transplantation
Osteoporosis
PINP, intact pro-collagen type I N-terminal pro-peptide
PTH, parathyroid hormone
TMV, Turnover, mineralization, and volume
TRAP5b, tartrate resistant acid phosphatase type 5b
X-Ray Microtomography
eGFR, estimated glomerular filtration rate
μCT, micro computed tomography
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
19
01
2022
accepted:
03
02
2022
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
Bone microarchitecture is an important component of bone quality and disturbances may reduce bone strength and resistance to trauma. Kidney transplant recipients have an excess risk of fractures, and bone loss affecting both trabecular and cortical bone compartments have been demonstrated after kidney transplantation. The primary aim of this study was to investigate the impact of kidney transplantation on trabecular and cortical bone microarchitecture, assessed by histomorphometry and micro computed tomography (μCT). Iliac crest bone biopsies, analyzed by bone histomorphometry and μCT, were performed at time of kidney transplantation and 12 months post-transplantation in an unselected cohort of 30 patients. Biochemical markers of mineral metabolism and bone turnover were measured at both time-points. At 12 months post-transplantation, bone turnover was low in 5 (17%) and normal in 25 (83%) patients. By histomorphometry, bone remodeling normalized, with decreases in eroded perimeters (4.0 to 2.1%,
Identifiants
pubmed: 35198658
doi: 10.1016/j.bonr.2022.101172
pii: S2352-1872(22)00007-9
pmc: PMC8851083
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101172Informations de copyright
© 2022 The Authors. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
PE reports personal fees from Amgen and Vifor-FMC. Remaining authors have no conflicts of interest to declare.
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