Impact of myocardial reperfusion on human plasma lipidome.

Cardiovascular medicine Lipidomics

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
18 Feb 2022
Historique:
received: 01 09 2021
revised: 20 11 2021
accepted: 21 01 2022
entrez: 24 2 2022
pubmed: 25 2 2022
medline: 25 2 2022
Statut: epublish

Résumé

The primary aim of the study is to investigate the temporal changes in plasma lipidome before and after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) and their association with myocardial injury. We found that 56% of the identified lipid species were significantly altered (corrected p< 0.05) in the first 24 h following reperfusion in patients with STEMI. Three lipid species, namely, acylcarnitine 18:2, TG 51:0, and LPC 17:1 were associated with a change in troponin concentration (delta troponin) and in-hospital cardiovascular events. Of these, acylcarnitine 18:2, and LPC 17:1 and their respective whole class levels, were significantly higher (p < 0.05) in the STEMI population than the age/sex-matched control subjects. Overall, our analyses showed a large shift in plasma lipidome in patients that undergo myocardial reperfusion. The differences found for acylcarnitines and LPC species and their association with both cardiac markers and cardiac outcomes need further validation.

Identifiants

DOI: 10.1016/j.isci.2022.103828 PMID: 35198888 PMC: PMC8850755
pubmed: 35198888
doi: 10.1016/j.isci.2022.103828
pii: S2589-0042(22)00098-0
pmc: PMC8850755
doi:

Types de publication

Journal Article

Langues

eng

Pagination

103828

Informations de copyright

© 2022 The Author(s).

Déclaration de conflit d'intérêts

All authors declare no conflicts relevant to the contents of this article.

Références

Circulation. 2016 Nov 22;134(21):1637-1650
pubmed: 27756783
Gen Physiol Biophys. 2004 Sep;23(3):337-46
pubmed: 15638121
Basic Res Cardiol. 1989 Mar-Apr;84(2):165-73
pubmed: 2730523
Am J Clin Nutr. 2016 Jun;103(6):1408-16
pubmed: 27099249
Circulation. 2007 May 29;115(21):2715-21
pubmed: 17502572
Crit Care Med. 2015 Jun;43(6):1255-64
pubmed: 25738856
Circulation. 2021 Feb 23;143(8):e254-e743
pubmed: 33501848
Med Sci Monit. 2018 Jun 18;24:4175-4182
pubmed: 29913478
Free Radic Biol Med. 1999 Jul;27(1-2):42-50
pubmed: 10443918
J Lipid Res. 2018 Oct;59(10):2001-2017
pubmed: 30115755
Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1378-87
pubmed: 24760988
J Nutr. 2009 Jun;139(6):1073-81
pubmed: 19369366
World J Cardiol. 2018 Sep 26;10(9):74-86
pubmed: 30344955
Circ Res. 1989 Feb;64(2):304-14
pubmed: 2783564
N Engl J Med. 2000 Oct 19;343(16):1148-55
pubmed: 11036120
Nat Rev Endocrinol. 2015 Oct;11(10):617-25
pubmed: 26303601
J Lipid Res. 2013 Oct;54(10):2898-908
pubmed: 23868910
Nat Rev Neurosci. 2007 Oct;8(10):743-54
pubmed: 17882252
Cardiovasc Res. 2019 Jan 1;115(1):179-189
pubmed: 29850765
Anal Chem. 2019 Mar 5;91(5):3590-3596
pubmed: 30758187
PLoS One. 2016 Feb 10;11(2):e0148361
pubmed: 26863521
Nutrients. 2015 Nov 13;7(11):9453-74
pubmed: 26580649
Clin Chem. 2017 Jan;63(1):73-81
pubmed: 28062612
Sci Rep. 2019 Aug 13;9(1):11742
pubmed: 31409856
J Am Coll Cardiol. 2002 Jun 5;39(11):1738-44
pubmed: 12039485
J Biol Chem. 2001 May 18;276(20):16683-9
pubmed: 11278967
J Lipid Res. 2020 Jan;61(1):105-115
pubmed: 31732502
JAMA. 2010 Jun 2;303(21):2148-55
pubmed: 20516415
Anal Chem. 2012 Feb 7;84(3):1483-90
pubmed: 22224852
Mol Cell Biochem. 1997 Jan;166(1-2):85-94
pubmed: 9046024
Circulation. 2014 May 6;129(18):1821-31
pubmed: 24622385
J Clin Invest. 2013 Jan;123(1):92-100
pubmed: 23281415
Am J Clin Nutr. 2017 Oct;106(4):973-983
pubmed: 28814398
Biochim Biophys Acta. 2016 Oct;1861(10):1513-24
pubmed: 26924249
Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2723-32
pubmed: 21903946
J Biol Chem. 2004 Apr 23;279(17):16971-9
pubmed: 14966134
J Am Heart Assoc. 2017 Feb 3;6(2):
pubmed: 28159823
J Biol Chem. 1992 Feb 25;267(6):3825-31
pubmed: 1740430
PLoS One. 2018 Apr 23;13(4):e0195172
pubmed: 29684044
Lipids. 2017 Jan;52(1):11-26
pubmed: 27914034
J Clin Invest. 1989 Mar;83(3):927-36
pubmed: 2921326
N Engl J Med. 2007 Sep 13;357(11):1121-35
pubmed: 17855673
Int J Mol Sci. 2019 Mar 06;20(5):
pubmed: 30845751
Circulation. 2005 Mar 1;111(8):1027-32
pubmed: 15723982
Circulation. 2004 Jun 29;109(25):3164-70
pubmed: 15184281
Am Heart J. 1994 Jul;128(1):61-7
pubmed: 8017285

Auteurs

Arun Surendran (A)

Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada.
Mass Spectrometry and Proteomics Core Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014 Kerala, India.
Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.

Negar Atefi (N)

Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada.

Umar Ismail (U)

Section of Cardiology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.

Ashish Shah (A)

Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.
Section of Cardiology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.

Amir Ravandi (A)

Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada.
Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.
Section of Cardiology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.

Classifications MeSH