Extracellular vesicles and immune response during pregnancy: A balancing act.
extracellular vesicles
gestational immunology
pregnancy
tolerance
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
31
01
2022
accepted:
09
02
2022
pubmed:
25
2
2022
medline:
15
6
2022
entrez:
24
2
2022
Statut:
ppublish
Résumé
The mechanisms underlying maternal tolerance of the semi- or fully-allogeneic fetus are intensely investigated. Across gestation, feto-placental antigens interact with the maternal immune system locally within the trophoblast-decidual interface and distantly through shed cells and soluble molecules that interact with maternal secondary lymphoid tissues. The discovery of extracellular vesicles (EVs) as local or systemic carriers of antigens and immune-regulatory molecules has added a new dimension to our understanding of immune modulation prior to implantation, during trophoblast invasion, and throughout the course of pregnancy. New data on immune-regulatory molecules, located on EVs or within their cargo, suggest a role for EVs in negotiating immune tolerance during gestation. Lessons from the field of transplant immunology also shed light on possible interactions between feto-placentally derived EVs and maternal lymphoid tissues. These insights illuminate a potential role for EVs in major obstetrical disorders. This review provides updated information on intensely studied, pregnancy-related EVs, their cargo molecules, and patterns of fetal-placental-maternal trafficking, highlighting potential immune pathways that might underlie immune suppression or activation in gestational health and disease. Our summary also underscores the likely need to broaden the definition of the maternal-fetal interface to systemic maternal immune tissues that might interact with circulating EVs.
Identifiants
pubmed: 35199366
doi: 10.1111/imr.13074
pmc: PMC9189022
mid: NIHMS1780304
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-122Subventions
Organisme : NICHD NIH HHS
ID : R01 HD103727
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148690
Pays : United States
Organisme : NICHD NIH HHS
ID : R37 HD086916
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130191
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL130191
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R37HD086916
Informations de copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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