Antibacterial Cascade Catalytic Glutathione-Depleting MOF Nanoreactors.

Animals Anti-Bacterial Agents / pharmacology Bacterial Infections / drug therapy Catalysis Glucose / metabolism Glutathione / metabolism Gram-Negative Bacteria / drug effects Gram-Positive Bacteria / drug effects Metal-Organic Frameworks Mice, Inbred BALB C Nanoparticles / chemistry Protons Reactive Oxygen Species / metabolism Wound Infection / drug therapy
GSH depletion antibacterial therapy metal−organic frameworks nanozyme reactive oxygen species

Journal

ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991

Informations de publication

Date de publication:
09 Mar 2022
Historique:
pubmed: 25 2 2022
medline: 31 3 2022
entrez: 24 2 2022
Statut: ppublish

Résumé

Nanozymes with peroxidase-like activity have great application potential in combating pathogenic bacterial infections and are expected to become an alternative to antibiotics. However, the near-neutral pH and high glutathione (GSH) levels in the bacterial infection microenvironment severely limit their applications in antibacterial therapy. In this work, a metal-organic framework (MOF)-based cascade catalytic glutathione-depleting system named MnFe

Identifiants

DOI: 10.1021/acsami.1c24231 PMID: 35199514
pubmed: 35199514
doi: 10.1021/acsami.1c24231
doi:

Substances chimiques

Anti-Bacterial Agents 0
Metal-Organic Frameworks 0
Protons 0
Reactive Oxygen Species 0
Glutathione GAN16C9B8O
Glucose IY9XDZ35W2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11104-11115

Auteurs

Xi Zhou (X)

Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
ORCID: 0000-0001-5302-5330

Shuai Zhang (S)

Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.

Yan Liu (Y)

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.

Jiashen Meng (J)

School of Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Muxue Wang (M)

Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.

Yaoji Sun (Y)

Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, People's Republic of China.

Linbo Xia (L)

Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.

Zhaozhi He (Z)

Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.

Wenxin Hu (W)

Harvard College, Harvard University, 209 Dunster Mail Center, 945 Memorial Drive, Cambridge, Massachusetts 02138, United States.

Lei Ren (L)

Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China.
ORCID: 0000-0003-2131-1601

Zhiwei Chen (Z)

Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, People's Republic of China.
ORCID: 0000-0001-6637-8194

Xingcai Zhang (X)

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
School of Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
ORCID: 0000-0001-7114-1095

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Structures macromoléculaires › Réseaux organométalliques › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Antibacterial Cascade Catalytic...
questionsmedicales.fr › Infection › Infection de plaie › Antibacterial Cascade Catalytic...