Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia.

Aging Animals Disease Models, Animal Hydrogen Peroxide / metabolism Mice Mitochondria / metabolism Muscle, Skeletal / metabolism Muscular Atrophy / metabolism Oxidative Stress Peroxiredoxin III / metabolism Quality of Life Sarcopenia / pathology Superoxide Dismutase-1 / genetics
aging hydrogen peroxide mitochondria peroxiredoxin3 sarcopenia

Journal

Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839

Informations de publication

Date de publication:
03 2022
Historique:
revised: 21 01 2022
received: 12 07 2021
accepted: 01 02 2022
pubmed: 25 2 2022
medline: 3 5 2022
entrez: 24 2 2022
Statut: ppublish

Résumé

Age-related muscle atrophy and weakness, or sarcopenia, are significant contributors to compromised health and quality of life in the elderly. While the mechanisms driving this pathology are not fully defined, reactive oxygen species, neuromuscular junction (NMJ) disruption, and loss of innervation are important risk factors. The goal of this study is to determine the impact of mitochondrial hydrogen peroxide on neurogenic atrophy and contractile dysfunction. Mice with muscle-specific overexpression of the mitochondrial H

Identifiants

DOI: 10.1111/acel.13569 PMID: 35199907 PMC: PMC8920438
pubmed: 35199907
doi: 10.1111/acel.13569
pmc: PMC8920438
doi:

Substances chimiques

Hydrogen Peroxide BBX060AN9V
Peroxiredoxin III EC 1.11.1.15
Superoxide Dismutase-1 EC 1.15.1.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13569

Subventions

Organisme : NIA NIH HHS
ID : R01 AG050676
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG064143
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG050911
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG051442
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG064143
Pays : United States
Organisme : BLRD VA
ID : IK6 BX005238
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG020591
Pays : United States
Organisme : BLRD VA
ID : IK6 BX005234
Pays : United States

Informations de copyright

© 2022 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

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Auteurs

Bumsoo Ahn (B)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
ORCID: 0000-0002-2743-7099

Rojina Ranjit (R)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.

Parker Kneis (P)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.

Hongyang Xu (H)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.

Katarzyna M Piekarz (KM)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
ORCID: 0000-0003-4710-9970

Willard M Freeman (WM)

Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
ORCID: 0000-0001-7027-999X

Michael Kinter (M)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Oklahoma Nathan Shock Center for Aging, Oklahoma City, Oklahoma, USA.

Arlan Richardson (A)

Oklahoma Nathan Shock Center for Aging, Oklahoma City, Oklahoma, USA.
Department of Biochemistry, OUHSC, Oklahoma City, Oklahoma, USA.
Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.

Qitao Ran (Q)

Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, Texas, USA.
ORCID: 0000-0002-2127-8349

Susan V Brooks (SV)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

Holly Van Remmen (H)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Oklahoma Nathan Shock Center for Aging, Oklahoma City, Oklahoma, USA.
Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.
Department of Physiology, OUHSC, Oklahoma City, Oklahoma, USA.
ORCID: 0000-0003-0883-0642

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Eucaryotes › Animaux › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Peroxiredoxin III › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Sarcopénie › Scavenging mitochondrial hydrogen peroxide by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 › Scavenging mitochondrial hydrogen peroxide by...