Clinical and Biological Factors Are Associated with Treatment-Resistant Depression.
Major Depressive Disorder (MDD)
biochemical markers
clinical features
treatment-resistant depression (TRD)
Journal
Behavioral sciences (Basel, Switzerland)
ISSN: 2076-328X
Titre abrégé: Behav Sci (Basel)
Pays: Switzerland
ID NLM: 101576826
Informations de publication
Date de publication:
03 Feb 2022
03 Feb 2022
Historique:
received:
13
12
2021
revised:
19
01
2022
accepted:
29
01
2022
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
Treatment-resistant depression (TRD) is a debilitating condition associated with unmet clinical needs. Few studies have explored clinical characteristics and serum biomarkers associated with TRD. We investigated whether there were differences in clinical and biochemical variables between patients affected by TRD than those without. We recruited 343 patients (165 males and 178 females) consecutively hospitalized for MDD to the inpatient clinics affiliated to the Fondazione IRCCS Policlinico, Milan, Italy ( TRD versus non-TRD patients resulted to be older ( We identified candidate biomarkers associated with TRD such as bilirubin plasma levels and NLR, to be confirmed by further studies. Moreover, TRD seems to be associated with unfavorable clinical factors such as a predisposition to suicidal behaviors. Future research should replicate these results to provide robust data in support of the identification of new targets of treatment and implementation of prevention strategies for TRD.
Sections du résumé
BACKGROUND
BACKGROUND
Treatment-resistant depression (TRD) is a debilitating condition associated with unmet clinical needs. Few studies have explored clinical characteristics and serum biomarkers associated with TRD.
AIMS
OBJECTIVE
We investigated whether there were differences in clinical and biochemical variables between patients affected by TRD than those without.
METHODS
METHODS
We recruited 343 patients (165 males and 178 females) consecutively hospitalized for MDD to the inpatient clinics affiliated to the Fondazione IRCCS Policlinico, Milan, Italy (
RESULTS
RESULTS
TRD versus non-TRD patients resulted to be older (
CONCLUSION
CONCLUSIONS
We identified candidate biomarkers associated with TRD such as bilirubin plasma levels and NLR, to be confirmed by further studies. Moreover, TRD seems to be associated with unfavorable clinical factors such as a predisposition to suicidal behaviors. Future research should replicate these results to provide robust data in support of the identification of new targets of treatment and implementation of prevention strategies for TRD.
Identifiants
pubmed: 35200285
pii: bs12020034
doi: 10.3390/bs12020034
pmc: PMC8869369
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondazione Cariplo
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