Nucleic Acids and Their Analogues for Biomedical Applications.
DNA nanotechnology
biomedical applications
biosensing
drug delivery
gene regulation
nanomaterials
nucleic acid
nucleic acid analogues
therapy
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
04 Feb 2022
04 Feb 2022
Historique:
received:
15
12
2021
revised:
20
01
2022
accepted:
25
01
2022
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
7
4
2022
Statut:
epublish
Résumé
Nucleic acids are emerging as powerful and functional biomaterials due to their molecular recognition ability, programmability, and ease of synthesis and chemical modification. Various types of nucleic acids have been used as gene regulation tools or therapeutic agents for the treatment of human diseases with genetic disorders. Nucleic acids can also be used to develop sensing platforms for detecting ions, small molecules, proteins, and cells. Their performance can be improved through integration with other organic or inorganic nanomaterials. To further enhance their biological properties, various chemically modified nucleic acid analogues can be generated by modifying their phosphodiester backbone, sugar moiety, nucleobase, or combined sites. Alternatively, using nucleic acids as building blocks for self-assembly of highly ordered nanostructures would enhance their biological stability and cellular uptake efficiency. In this review, we will focus on the development and biomedical applications of structural and functional natural nucleic acids, as well as the chemically modified nucleic acid analogues over the past ten years. The recent progress in the development of functional nanomaterials based on self-assembled DNA-based platforms for gene regulation, biosensing, drug delivery, and therapy will also be presented. We will then summarize with a discussion on the advanced development of nucleic acid research, highlight some of the challenges faced and propose suggestions for further improvement.
Identifiants
pubmed: 35200353
pii: bios12020093
doi: 10.3390/bios12020093
pmc: PMC8869748
pii:
doi:
Substances chimiques
Nucleic Acids
0
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Health and Medical Research Fund
ID : 07181396 and 05160336
Organisme : National Science Foundation of China
ID : 21574109 and 21778043
Organisme : The Science and Technology Innovation Committee of Shenzhen Municipality 2020 Basic Re-search General Program
ID : JCYJ20190812160203619
Organisme : Hong Kong Research Grants Council
ID : 21300314, 11304719, 11301220
Organisme : City University of Hong Kong
ID : 9680104, 7004911, 7004655
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