Algal-Derived Halogenated Sesquiterpenes from
(−)-elatol
Biomphalaria
Schistosoma mansoni
larvicide
marine natural products
molluscicide
obtusol
rogiolol
terpenes
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
29 Jan 2022
29 Jan 2022
Historique:
received:
23
12
2021
revised:
20
01
2022
accepted:
22
01
2022
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
18
3
2022
Statut:
epublish
Résumé
Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species,
Identifiants
pubmed: 35200640
pii: md20020111
doi: 10.3390/md20020111
pmc: PMC8874501
pii:
doi:
Substances chimiques
Anthelmintics
0
elatol
55303-97-4
Molluscacides
0
obtusol
0
Sesquiterpenes
0
Spiro Compounds
0
rogiolol
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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