Mitophagy in carcinogenesis and cancer treatment.
Autophagy
Cancer
Homeostasis
Mitophagy
Journal
Discover. Oncology
ISSN: 2730-6011
Titre abrégé: Discov Oncol
Pays: United States
ID NLM: 101775142
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
received:
10
10
2021
accepted:
17
11
2021
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson's disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.
Identifiants
pubmed: 35201480
doi: 10.1007/s12672-021-00454-1
pii: 10.1007/s12672-021-00454-1
pmc: PMC8777571
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
58Subventions
Organisme : The Russian Foundation for Basic Research
ID : 19-015-00332
Organisme : The Russian Science Foundation
ID : 19-15-00125
Organisme : Cancerföreningen i Stockholm
ID : 181301
Organisme : Cancerfonden
ID : 190345
Informations de copyright
© 2021. The Author(s).
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