Development of high-affinity nanobodies specific for Na

Animals Cells, Cultured Escherichia coli / genetics Humans Long QT Syndrome / metabolism Mammals / metabolism Protein Isoforms / genetics Recombinant Proteins / genetics Single-Domain Antibodies / genetics Voltage-Gated Sodium Channels / genetics
FRET Lama glama Na(V)1.4 Na(V)1.5 X-ray diffraction biolayer interferometry hIPSC-CM nanobody voltage-gated sodium channel

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
04 2022
Historique:
received: 19 01 2022
revised: 16 02 2022
accepted: 18 02 2022
pubmed: 25 2 2022
medline: 27 4 2022
entrez: 24 2 2022
Statut: ppublish

Résumé

Voltage-gated sodium channels, Na

Identifiants

DOI: 10.1016/j.jbc.2022.101763 PMID: 35202650 PMC: PMC8935509
pubmed: 35202650
pii: S0021-9258(22)00203-4
doi: 10.1016/j.jbc.2022.101763
pmc: PMC8935509
pii:
doi:

Substances chimiques

Protein Isoforms 0
Recombinant Proteins 0
Single-Domain Antibodies 0
Voltage-Gated Sodium Channels 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101763

Subventions

Organisme : NCRR NIH HHS
ID : S10 RR027050
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089502
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM111244
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM109441
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128743
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest S. B. G. is a founder and holds equity in Advanced Molecular Sciences LLC. S. B. G. is consultant to Genesis Therapeutics and Xinthera, Inc. All other authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Lakshmi Srinivasan (L)

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Vanina Alzogaray (V)

Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.

Dakshnamurthy Selvakumar (D)

ForteBio, Sartorius BioAnalytical Instruments, Fremont, California, USA.

Sara Nathan (S)

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Jesse B Yoder (JB)

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Katharine M Wright (KM)

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Sebastián Klinke (S)

Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.

Justin N Nwafor (JN)

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

María S Labanda (MS)

Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.

Fernando A Goldbaum (FA)

Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.

Arne Schön (A)

Department of Biology, The Johns Hopkins University Krieger School of Arts and Science, Baltimore, Maryland, USA.

Ernesto Freire (E)

Department of Biology, The Johns Hopkins University Krieger School of Arts and Science, Baltimore, Maryland, USA.

Gordon F Tomaselli (GF)

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

L Mario Amzel (LM)

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Manu Ben-Johny (M)

Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA.

Sandra B Gabelli (SB)

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: gabelli@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Cellules › Cellules cultivées › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Syndrome du QT long › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Fragments d'immunoglobuline › Fragments Fab d'immunoglobuline › Anticorps à domaine unique › Development of high-affinity nanobodies specific for Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Development of high-affinity nanobodies specific for Na