Species-Specific Paternal Age Effects and Sperm Methylation Levels of Developmentally Important Genes.
age-related differentially methylated regions (ageDMRs)
bisulfite pyrosequencing
mammalian male germline
paternal age effect
species-specific epigenetic marks
sperm DNA methylation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
19 02 2022
19 02 2022
Historique:
received:
15
12
2021
revised:
11
01
2022
accepted:
15
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
9
4
2022
Statut:
epublish
Résumé
A growing number of sperm methylome analyses have identified genomic loci that are susceptible to paternal age effects in a variety of mammalian species, including human, bovine, and mouse. However, there is little overlap between different data sets. Here, we studied whether or not paternal age effects on the sperm epigenome have been conserved in mammalian evolution and compared methylation patterns of orthologous regulatory regions (mainly gene promoters) containing both conserved and non-conserved CpG sites in 94 human, 36 bovine, and 94 mouse sperm samples, using bisulfite pyrosequencing. We discovered three (
Identifiants
pubmed: 35203380
pii: cells11040731
doi: 10.3390/cells11040731
pmc: PMC8870257
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : HA 1374/19-1
Organisme : European Commission
ID : 692185 (ERAofART)
Organisme : European Commission
ID : 836421 (NeuroAPA)
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