The Cytogenetic Profile of Primary and Secondary Plasma Cell Leukemia: Etiopathogenetic Perspectives, Prognostic Impact and Clinical Relevance to Newly Diagnosed Multiple Myeloma with Differential Circulating Clonal Plasma Cells.
FISH
circulating plasma cells
clonal evolution
cytogenetics
multiple myeloma
primary plasma cell leukemia
secondary plasma cell leukemia
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
19 Jan 2022
19 Jan 2022
Historique:
received:
30
11
2021
revised:
08
01
2022
accepted:
10
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Plasma cell leukemia (PCL) is a rare and aggressive plasma cell dyscrasia that may appear as de-novo leukemia (pPCL) or on the basis of a pre-existing multiple myeloma (MM), called secondary plasma cell leukemia (sPCL). In this prospective study, we have applied a broad panel of FISH probes in 965 newly diagnosed MM (NDMM) and 44 PCL cases of both types to reveal the particular cytogenetic differences among the three plasma cell dyscrasias. In order to evaluate the frequency and patterns of clonal evolution, the same FISH panel was applied both at diagnosis and at the time of first relapse for 81 relapsed MM patients and both at MM diagnosis and during sPCL transformation for the 19 sPCL cases described here. pPCL was characterized by frequent
Identifiants
pubmed: 35203419
pii: biomedicines10020209
doi: 10.3390/biomedicines10020209
pmc: PMC8869452
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Cancer. 2009 Dec 15;115(24):5734-9
pubmed: 19877113
Leuk Res. 2013 Oct;37(10):1251-7
pubmed: 23927993
Blood Cancer J. 2020 Jun 19;10(6):70
pubmed: 32555163
Leukemia. 2014 Oct;28(10):2060-5
pubmed: 24618735
Med Oncol. 2008;25(2):154-60
pubmed: 18488157
Blood Adv. 2022 Jan 25;6(2):441-451
pubmed: 34653241
Blood Cancer J. 2021 Feb 4;11(2):23
pubmed: 33563906
Haematologica. 2019 Jul;104(7):1440-1450
pubmed: 30733268
Leuk Lymphoma. 2017 Jul;58(7):1538-1547
pubmed: 27819179
Blood Cancer J. 2017 Aug 25;7(8):e597
pubmed: 28841209
Ann Oncol. 2011 Jul;22(7):1628-1635
pubmed: 21252060
Leukemia. 2001 Jun;15(6):981-6
pubmed: 11417487
Oncotarget. 2017 Jun 16;8(45):79517-79526
pubmed: 29108331
J Oncol Pharm Pract. 2020 Jul;26(5):1274-1278
pubmed: 31865846
Blood Cancer J. 2021 Dec 2;11(12):192
pubmed: 34857730
J Clin Oncol. 2016 Jun 20;34(18):2125-32
pubmed: 27114594
Leuk Lymphoma. 2019 Jan;60(1):118-123
pubmed: 29965787
Leukemia. 2014 Jan;28(1):222-5
pubmed: 23958922
Cancers (Basel). 2020 Nov 04;12(11):
pubmed: 33158030
Leukemia. 2008 May;22(5):1044-52
pubmed: 18216867
Genes Chromosomes Cancer. 2009 Jul;48(7):624-36
pubmed: 19396865
Blood Cancer J. 2018 Nov 19;8(12):117
pubmed: 30455467
Blood. 2012 Aug 2;120(5):1060-6
pubmed: 22529291
Am J Hematol. 2014 Feb;89(2):145-50
pubmed: 24123068
Clin Hematol Int. 2020 Jul 19;2(4):133-142
pubmed: 34595454
Blood Cancer J. 2019 Mar 26;9(4):39
pubmed: 30914633
Cancers (Basel). 2021 Sep 29;13(19):
pubmed: 34638381
Leukemia. 2017 Oct;31(10):2094-2103
pubmed: 28104919
Leukemia. 2018 Jan;32(1):131-138
pubmed: 28655925
Br J Haematol. 2018 Mar;180(6):831-839
pubmed: 29315478
Blood. 2001 Feb 1;97(3):822-5
pubmed: 11157506
Blood. 2015 Dec 17;126(25):2713-9
pubmed: 26516228
Am J Hematol. 2020 Dec;95(12):1562-1571
pubmed: 32936982
Front Oncol. 2019 Jan 09;8:665
pubmed: 30687640
Cancers (Basel). 2021 Aug 11;13(16):
pubmed: 34439201
Clin Cancer Res. 2013 Jun 15;19(12):3130-42
pubmed: 23613318
Blood Cancer J. 2016 Mar 11;6:e401
pubmed: 26967818
Arch Intern Med. 1974 May;133(5):813-8
pubmed: 4821776
Hemasphere. 2019 Oct 01;3(6):e300
pubmed: 31976475
Br J Haematol. 2013 Aug;162(4):555-8
pubmed: 23718846
Blood. 2000 Apr 15;95(8):2691-8
pubmed: 10753852
Int J Lab Hematol. 2019 Feb;41(1):5-14
pubmed: 29971938
Haematologica. 2017 Jun;102(6):1099-1104
pubmed: 28255016
Rom J Morphol Embryol. 2012;53(4):1073-6
pubmed: 23303035
Blood. 2012 Aug 2;120(5):1067-76
pubmed: 22498740
Blood. 1999 Feb 1;93(3):1032-7
pubmed: 9920853
Leuk Res. 2009 Feb;33(2):259-62
pubmed: 18676019
Blood. 2011 May 5;117(18):4691-5
pubmed: 21292775
Clin Cancer Res. 2013 Jun 15;19(12):3247-58
pubmed: 23599371
Curr Oncol Rep. 2019 Jan 28;21(1):8
pubmed: 30689121
Genes Chromosomes Cancer. 2015 Apr;54(4):210-21
pubmed: 25533355
Am J Hematol. 2013 Jan;88(1):16-23
pubmed: 23044976
Blood Cancer J. 2018 Nov 15;8(12):116
pubmed: 30442928
Cancer Genet Cytogenet. 2005 Jan 15;156(2):150-3
pubmed: 15642395
Br J Haematol. 2020 Aug;190(4):e242-e245
pubmed: 32525557