Disinhibition-Like Behavior Correlates with Frontal Cortex Damage in an Animal Model of Chronic Alcohol Consumption and Thiamine Deficiency.
Wernicke’s encephalopathy
apoptosis
cell damage
chronic alcohol
disinhibition
lipid peroxidation
nitrosative stress
nutritional deficit
recognition memory
thiamine deficiency
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
25 Jan 2022
25 Jan 2022
Historique:
received:
30
11
2021
revised:
08
01
2022
accepted:
18
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Wernicke-Korsakoff syndrome (WKS) is induced by thiamine deficiency (TD) and mainly related to alcohol consumption. Frontal cortex dysfunction has been associated with impulsivity and disinhibition in WKS patients. The pathophysiology involves oxidative stress, excitotoxicity and inflammatory responses leading to neuronal death, but the relative contributions of each factor (alcohol and TD, either isolated or in interaction) to these phenomena are still poorly understood. A rat model was used by forced consumption of 20% (
Identifiants
pubmed: 35203470
pii: biomedicines10020260
doi: 10.3390/biomedicines10020260
pmc: PMC8869694
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : FEDER (European Union)/ MINISTERIO DE CIENCIA E INNOVACIÓN (MICINN) / Agencia Es-tatal de Investigación (Spain)
ID : RTI2018-099535-B-I00
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