Circulating LIGHT (TNFSF14) and Interleukin-18 Levels in Sepsis-Induced Multi-Organ Injuries.
LIGHT
acute hypoxic respiratory failure
acute kidney injury
acute respiratory distress syndrome
interleukin-18
sepsis
viral infections
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
25 Jan 2022
25 Jan 2022
Historique:
received:
23
11
2021
revised:
09
01
2022
accepted:
13
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
The novel therapeutic target cytokine LIGHT (TNFSF14) was recently shown to play a major role in COVID-19-induced acute respiratory distress syndrome (ARDS). This study aims to investigate the associations of plasma LIGHT and another potentially targetable cytokine, interleukin-18 (IL-18), with ARDS, acute hypoxic respiratory failure (AHRF), or acute kidney injury (AKI), caused by non-COVID-19 viral or bacterial sepsis. A total of 280 subjects diagnosed with sepsis, including 91 cases with sepsis triggered by viral infections, were investigated in this cohort study. Day 0 plasma LIGHT and IL-18, as well as 59 other biomarkers (cytokines, chemokines, and acute-phase reactants) were measured by sensitive bead immunoassay and associated with symptom severity. We observed significantly increased LIGHT level in both bacterial sepsis patients (
Identifiants
pubmed: 35203474
pii: biomedicines10020264
doi: 10.3390/biomedicines10020264
pmc: PMC8869623
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cerecor
ID : NA
Organisme : Children's Hospital of Philadelphia
ID : NA
Commentaires et corrections
Type : UpdateOf
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