Impact of Maternal Obesity on Liver Disease in the Offspring: A Comprehensive Transcriptomic Analysis and Confirmation of Results in a Murine Model.
developmental origins of health and disease
liver disease
maternal obesity
non-alcoholic fatty liver disease
transcriptomics
whole-genome expression analysis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
27 Jan 2022
27 Jan 2022
Historique:
received:
30
11
2021
revised:
16
01
2022
accepted:
24
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
The global obesity epidemic particularly affects women of reproductive age. Offspring of obese mothers suffer from an increased risk of liver disease but the molecular mechanisms involved remain unknown. We performed an integrative genomic analysis of datasets that investigated the impact of maternal obesity on the hepatic gene expression profile of the offspring in mice. Furthermore, we developed a murine model of maternal obesity and studied the development of liver disease and the gene expression profile of the top dysregulated genes by quantitative real-time polymerase chain reaction (qPCR). Our data are available for interactive exploration on our companion webpage. We identified five publicly available datasets relevant to our research question. Pathways involved in metabolism, the innate immune system, the clotting cascade, and the cell cycle were consistently dysregulated in the offspring of obese mothers. Concerning genes involved in the development of liver disease,
Identifiants
pubmed: 35203502
pii: biomedicines10020294
doi: 10.3390/biomedicines10020294
pmc: PMC8869223
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swiss National Science Foundation
ID : 182471
Pays : Switzerland
Organisme : Fondation Francis & Marie-France Minkoff
ID : NA
Organisme : Fondation Leenaards
ID : 5489
Références
Mol Nutr Food Res. 2017 Jan;61(1):
pubmed: 27129739
World J Gastroenterol. 2015 Sep 28;21(36):10262-73
pubmed: 26420954
Acta Physiol (Oxf). 2014 Jan;210(1):215-27
pubmed: 24224789
Am J Epidemiol. 2019 Aug 1;188(8):1503-1511
pubmed: 31107539
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
N Engl J Med. 1985 Feb 14;312(7):395-9
pubmed: 3844050
Sci Rep. 2021 Feb 3;11(1):2884
pubmed: 33536442
J Lipid Res. 2019 Jul;60(7):1250-1259
pubmed: 31064776
Cell Death Differ. 2009 Jul;16(7):1053-61
pubmed: 19325570
J Cell Physiol. 2007 Jan;210(1):1-6
pubmed: 17063460
Int J Obes (Lond). 2019 Jun;43(6):1231-1243
pubmed: 30568270
J Hepatol. 2007 Jun;46(6):1026-33
pubmed: 17336417
Sci Rep. 2017 Sep 27;7(1):12361
pubmed: 28955037
Hepatology. 2013 Jul;58(1):128-38
pubmed: 23315950
N Engl J Med. 2019 Dec 19;381(25):2440-2450
pubmed: 31851800
J Clin Med. 2021 Feb 11;10(4):
pubmed: 33670126
J Cell Physiol. 2019 Nov;234(11):20533-20545
pubmed: 31026065
Front Endocrinol (Lausanne). 2016 Jan 19;6:193
pubmed: 26834701
BMC Public Health. 2009 Mar 25;9:88
pubmed: 19320986
Nucleic Acids Res. 2019 Jan 8;47(D1):D711-D715
pubmed: 30357387
World J Gastroenterol. 2016 Jan 14;22(2):823-32
pubmed: 26811628
BMC Pregnancy Childbirth. 2015 Oct 16;15:266
pubmed: 26475596
J Hepatol. 2021 Nov;75(5):1042-1048
pubmed: 34289397
PeerJ. 2014 Jun 19;2:e453
pubmed: 25024921
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
Arch Intern Med. 2001 Jul 9;161(13):1581-6
pubmed: 11434789
J Hepatol. 2010 Jun;52(6):913-20
pubmed: 20413174
Metabolites. 2021 Aug 10;11(8):
pubmed: 34436472
J Hepatol. 2018 May;68(5):978-985
pubmed: 29331341
J Endocrinol. 2008 Sep;198(3):635-43
pubmed: 18603607
Gastroenterology. 2015 Oct;149(5):1226-1239.e4
pubmed: 26099527
PLoS One. 2017 Apr 17;12(4):e0175675
pubmed: 28414763
Nat Rev Endocrinol. 2020 Nov;16(11):654-667
pubmed: 32764725
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
pubmed: 23193258
BMC Bioinformatics. 2017 Mar 2;18(1):142
pubmed: 28249561
Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503
pubmed: 31691815
Hepatol Commun. 2020 Aug 09;4(10):1392-1403
pubmed: 33024911
J Am Heart Assoc. 2021 Sep 7;10(17):e020717
pubmed: 34431359
Int J Obes (Lond). 2019 Apr;43(4):735-743
pubmed: 30006584
J Clin Invest. 2007 Aug;117(8):2051-8
pubmed: 17671639
Bioinformatics. 2007 Jul 15;23(14):1846-7
pubmed: 17496320
Nutr Metab Insights. 2016 Feb 16;8(Suppl 1):41-7
pubmed: 26917970
PLoS One. 2013 Nov 05;8(11):e78623
pubmed: 24223833
Gut. 2021 Aug 24;:
pubmed: 34429385
Hypertens Res. 2018 Jun;41(6):394-405
pubmed: 29636553
J Lipid Res. 2021;62:100136
pubmed: 34673018
C R Biol. 2003 Oct-Nov;326(10-11):1079-82
pubmed: 14744116
Lancet. 2019 Dec 22;392(10165):2705-2717
pubmed: 30554783
Cell Metab. 2014 Sep 2;20(3):512-25
pubmed: 25043817
PLoS One. 2014 Mar 03;9(3):e90335
pubmed: 24594983
J Hepatol. 2020 Sep;73(3):603-615
pubmed: 32593682
J Physiol. 2018 Dec;596(23):5823-5837
pubmed: 29516496
Nature. 2021 Jul;595(7869):730-734
pubmed: 34290403
Gut. 2016 Jul;65(7):1202-14
pubmed: 26838599
J Physiol. 2018 Oct;596(19):4611-4628
pubmed: 29972240
Cancer Cell. 2012 Apr 17;21(4):504-16
pubmed: 22516259
Nature. 2004 Dec 16;432(7019):917-21
pubmed: 15531878
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Arch Pediatr Adolesc Med. 2007 Dec;161(12):1205-10
pubmed: 18056567
Hepatology. 2007 Jun;45(6):1375-81
pubmed: 17518368
Gastroenterology. 2018 Mar;154(4):965-975
pubmed: 29158192
J Clin Lipidol. 2020 Nov - Dec;14(6):807-817
pubmed: 33023859
Sci Rep. 2021 Mar 26;11(1):6980
pubmed: 33772054
Sci Rep. 2018 Nov 7;8(1):16502
pubmed: 30405201
J Hepatol. 2010 Nov;53(5):934-40
pubmed: 20675007
Hepatology. 2012 Nov;56(5):1751-9
pubmed: 22707395
Nat Commun. 2018 Feb 12;9(1):636
pubmed: 29434210
Hepatology. 2014 Jul;60(1):334-48
pubmed: 24619965
Int J Obes (Lond). 2016 Nov;40(11):1608-1618
pubmed: 27528251
NCHS Data Brief. 2020 Nov;(392):1-8
pubmed: 33270551
Cell. 2012 Feb 3;148(3):556-67
pubmed: 22304921