The Relationships between Gut Microbiota and Diabetes Mellitus, and Treatments for Diabetes Mellitus.
Bacteroides
Firmicutes
diabetes mellitus
inflammation
microbiota
nutraceuticals
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
28 Jan 2022
28 Jan 2022
Historique:
received:
15
12
2021
revised:
15
01
2022
accepted:
26
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Diabetes mellitus is considered to be a global epidemic. The combination of genetic susceptibility and an unhealthy lifestyle is considered to be the main trigger of this metabolic disorder. Recently, there has been increased interest in the roles of gut microbiota as a new potential contributor to this epidemic. Research, in recent years, has contributed to an in-depth characterization of the human microbiome and its associations with various diseases, including metabolic diseases and diabetes mellitus. It is known that diet can change the composition of gut microbiota, but it is unclear how this, in turn, may influence metabolism. The main objective of this review is to evaluate the pathogenetic association between microbiota and diabetes and to explore any new therapeutic agents, including nutraceuticals that may modulate the microbiota. We also look at several mechanisms involved in this process. There is a clear, bidirectional relationship between microbiota and diabetes. Current treatments for diabetes influence microbiota in various ways, some beneficial, but others with still unclear effects. Microbiota-aimed treatments have seen no real-world significant effects on the progression of diabetes and its complications, with more studies needed in order to find a really beneficial agent.
Identifiants
pubmed: 35203519
pii: biomedicines10020308
doi: 10.3390/biomedicines10020308
pmc: PMC8869176
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Diabetes Ther. 2017 Apr;8(2):293-307
pubmed: 28130771
Front Pediatr. 2019 Feb 27;7:47
pubmed: 30873394
Diabetes Metab Syndr. 2018 Sep;12(5):617-624
pubmed: 29661605
Front Pharmacol. 2022 Jan 03;12:794103
pubmed: 35046817
Dig Dis. 2017;35(3):241-245
pubmed: 28249273
Exp Biol Med (Maywood). 2018 Jan;243(1):34-44
pubmed: 29171288
Sci Rep. 2018 Nov 14;8(1):16791
pubmed: 30429496
Iran J Med Sci. 2013 Mar;38(1):38-43
pubmed: 23645956
Diabetes Care. 2021 Mar;44(3):663-671
pubmed: 33441419
Benef Microbes. 2010 Jun;1(2):189-96
pubmed: 21840806
Mol Nutr Food Res. 2019 Nov;63(22):e1900457
pubmed: 31433912
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 1;1043:187-201
pubmed: 27561968
Int J Mol Sci. 2021 Mar 30;22(7):
pubmed: 33808194
Diabetes Metab. 2021 Sep;47(5):101223
pubmed: 33429063
Front Nutr. 2021 Jan 13;7:612773
pubmed: 33521039
J Diabetes Metab Disord. 2017 Jun 2;16:23
pubmed: 28589103
Cell Res. 2020 Jun;30(6):492-506
pubmed: 32433595
J Nutr. 1997 May;127(5):717-23
pubmed: 9164992
Nutrition. 2012 May;28(5):539-43
pubmed: 22129852
Front Microbiol. 2018 Jun 29;9:1417
pubmed: 30008707
Nutrients. 2020 Jun 19;12(6):
pubmed: 32575561
Arch Drug Inf. 2008 Jul;1(1):35-41
pubmed: 20157366
Diabetes Res Clin Pract. 2014 Oct;106(1):e3-6
pubmed: 25172519
Life (Basel). 2020 Sep 11;10(9):
pubmed: 32932871
Diabetes Care. 2014 Aug;37(8):2343-50
pubmed: 24824547
Diabetes Metab. 2017 Apr;43(2):163-166
pubmed: 27745826
Mol Nutr Food Res. 2014 Jul;58(7):1513-8
pubmed: 24687809
Gut Microbes. 2020 May 3;11(3):253-264
pubmed: 32005089
Nat Commun. 2017 Nov 27;8(1):1785
pubmed: 29176714
Clin Nutr. 2016 Aug;35(4):819-25
pubmed: 26209256
Microb Pathog. 2018 Dec;125:454-462
pubmed: 30316007
Anaerobe. 2013 Dec;24:4-11
pubmed: 23999246
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5934-E5943
pubmed: 27638207
Benef Microbes. 2017 Apr 26;8(2):243-255
pubmed: 28008783
Sci Rep. 2015 Sep 23;5:14405
pubmed: 26396057
J Dairy Res. 2008 May;75(2):189-95
pubmed: 18474136
Oxid Med Cell Longev. 2017;2017:3831972
pubmed: 28357027
J Pharmacol Exp Ther. 2018 Jun;365(3):676-687
pubmed: 29674332
Diabetologia. 2015 Oct;58(10):2206-17
pubmed: 26224102
Sci Rep. 2016 Sep 16;6:33251
pubmed: 27633081
Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1165-1172
pubmed: 31336460
Eur Cardiol. 2019 Apr;14(1):50-59
pubmed: 31131037
Microorganisms. 2019 Jan 10;7(1):
pubmed: 30634578
Biomed Res. 2015;36(1):63-70
pubmed: 25749152
Nature. 2015 Dec 10;528(7581):262-266
pubmed: 26633628
Methods Mol Biol. 2014;1198:137-45
pubmed: 25270928
Eur J Pharm Sci. 2021 Mar 1;158:105668
pubmed: 33301903
Science. 2015 Apr 3;348(6230):80-6
pubmed: 25838377
Ann Nutr Metab. 2013;63(1-2):1-9
pubmed: 23899653
Diabetologia. 2018 Aug;61(8):1838-1848
pubmed: 29797022
World J Gastroenterol. 2007 May 28;13(20):2826-32
pubmed: 17569118
Sci Rep. 2019 Oct 30;9(1):15582
pubmed: 31666597
PeerJ. 2018 Mar 1;6:e4446
pubmed: 29507837
Lipids Health Dis. 2012 Feb 22;11:29
pubmed: 22356933
Food Funct. 2017 Sep 20;8(9):3155-3164
pubmed: 28782784
Front Endocrinol (Lausanne). 2020 Feb 26;11:78
pubmed: 32174888
Horm Metab Res. 1996 Sep;28(9):456-63
pubmed: 8911983
Front Endocrinol (Lausanne). 2020 Nov 17;11:635
pubmed: 33312157
Gut. 2021 Jun;70(6):1174-1182
pubmed: 33272977
J Diabetes. 2015 Sep;7(5):729-39
pubmed: 25327485
Biochem J. 2017 May 16;474(11):1823-1836
pubmed: 28512250
Antioxidants (Basel). 2021 Feb 10;10(2):
pubmed: 33578702
PLoS One. 2011;6(10):e25792
pubmed: 22043294
Am J Clin Nutr. 2011 May;93(5):1062-72
pubmed: 21389180
Pharmacol Res. 2020 Sep;159:104947
pubmed: 32492488
Front Endocrinol (Lausanne). 2014 Jun 05;5:85
pubmed: 24926285
Int J Mol Sci. 2019 Sep 30;20(19):
pubmed: 31575045
Diabetes Ther. 2014 Dec;5(2):355-66
pubmed: 25424969
Cardiovasc Diabetol. 2018 Apr 27;17(1):62
pubmed: 29703207
Diabetol Metab Syndr. 2018 Jun 19;10:51
pubmed: 29946368
Diabetes Care. 2001 Mar;24(3):489-94
pubmed: 11289473
Sci Rep. 2019 Aug 29;9(1):12515
pubmed: 31467327
Turk J Gastroenterol. 2019 Dec;30(12):1008
pubmed: 31854304
Br J Pharmacol. 1992 Apr;105(4):1009-13
pubmed: 1504710
Biomed Pharmacother. 2016 Dec;84:1008-1018
pubmed: 27768926
PLoS One. 2019 Dec 31;14(12):e0226372
pubmed: 31891582
Steroids. 2021 Jan;165:108757
pubmed: 33161055
Diabetes Metab Res Rev. 2018 Sep;34(6):e3010
pubmed: 29637693
Cardiovasc Diabetol. 2019 Feb 28;18(1):20
pubmed: 30819210
Best Pract Res Clin Endocrinol Metab. 2009 Aug;23(4):479-86
pubmed: 19748065
Front Pharmacol. 2018 Nov 23;9:1354
pubmed: 30532706
PLoS One. 2014 Mar 26;9(3):e92193
pubmed: 24670791
Genes (Basel). 2017 Sep 30;8(10):
pubmed: 28973971
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6
pubmed: 20679230
Transl Res. 2016 Jan;167(1):214-27
pubmed: 25980926
J Immunol. 2015 Nov 15;195(10):4999-5010
pubmed: 26466961
J Cell Biochem. 2018 Jan;119(1):105-110
pubmed: 28569437
Front Endocrinol (Lausanne). 2022 Jan 10;12:814770
pubmed: 35095773
Biosci Biotechnol Biochem. 2008 Feb;72(2):572-6
pubmed: 18256465
Endocr Connect. 2016 Jan;5(1):1-9
pubmed: 26555712
World J Diabetes. 2014 Oct 15;5(5):697-710
pubmed: 25317247
PLoS One. 2017 Oct 16;12(10):e0184735
pubmed: 29036231
Amino Acids. 2017 Dec;49(12):2083-2090
pubmed: 28932911
Appl Environ Microbiol. 2014 Oct;80(19):5935-43
pubmed: 25038099
BMC Med. 2013 Feb 21;11:46
pubmed: 23433344
J Lipid Res. 2009 Oct;50(10):1955-66
pubmed: 19346330
Microb Pathog. 2017 Sep;110:630-636
pubmed: 28739439
EBioMedicine. 2019 Jan;39:591-602
pubmed: 30553752
Biomed Pharmacother. 2021 Jan;133:110966
pubmed: 33171401
World J Gastroenterol. 2021 Nov 21;27(43):7446-7461
pubmed: 34887642
Br J Nutr. 2017 Mar;117(6):804-813
pubmed: 28367765
Mol Immunol. 2019 Aug;112:322-329
pubmed: 31238287
Endocrinol Nutr. 2016 Dec;63(10):560-568
pubmed: 27633134
J Appl Microbiol. 2009 Nov;107(5):1681-6
pubmed: 19457033
Lipids. 2015 Jul;50(7):681-9
pubmed: 26007321
J Clin Endocrinol Metab. 2016 Jan;101(1):233-42
pubmed: 26505825
J Ethnopharmacol. 2016 Dec 24;194:717-726
pubmed: 27751827
Diabetologia. 2017 Jun;60(6):943-951
pubmed: 28434033
Food Funct. 2020 Jul 1;11(7):6528-6541
pubmed: 32638790
Eur J Nutr. 2017 Jun;56(4):1535-1550
pubmed: 26988693
J Diabetes Res. 2016;2016:2093171
pubmed: 27631013
Front Immunol. 2019 Mar 11;10:277
pubmed: 30915065
Microorganisms. 2019 Aug 21;7(9):
pubmed: 31438634
Microb Pathog. 2017 Oct;111:362-369
pubmed: 28912092
Front Endocrinol (Lausanne). 2020 Mar 24;11:125
pubmed: 32265832
Cytokine. 2020 Jul;131:155101
pubmed: 32315958
Nutrients. 2019 Aug 18;11(8):
pubmed: 31426593
J Nephrol. 2017 Dec;30(6):719-727
pubmed: 28933050
Nature. 2014 Oct 9;514(7521):181-6
pubmed: 25231862
ISME J. 2010 Feb;4(2):232-41
pubmed: 19865183
Front Immunol. 2020 Oct 16;11:571731
pubmed: 33178196
Diabet Med. 2021 Feb;38(2):e14415
pubmed: 33025587
Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):294-301
pubmed: 29634493
Nature. 2019 Oct;574(7776):117-121
pubmed: 31534227
Diabetes Metab. 2020 Apr;46(2):164-168
pubmed: 31816432
Gut Pathog. 2019 Oct 14;11:49
pubmed: 31636716
J Clin Endocrinol Metab. 2019 Oct 1;104(10):4427-4440
pubmed: 31188437
Diabetes Metab. 2016 Nov;42(5):303-315
pubmed: 27179626
Gut. 2020 Jul;69(7):1218-1228
pubmed: 32066625
Diabetes Obes Metab. 2017 Apr;19(4):579-589
pubmed: 28009106
PLoS One. 2010 Feb 05;5(2):e9085
pubmed: 20140211
Nat Microbiol. 2019 Jan;4(1):35-45
pubmed: 30546094
Diabetes Metab Res Rev. 2002 Mar-Apr;18 Suppl 2:S10-5
pubmed: 11921433
J Transl Med. 2017 Apr 8;15(1):73
pubmed: 28388917
Nature. 2013 Jun 6;498(7452):99-103
pubmed: 23719380
Front Pharmacol. 2020 Sep 23;11:581470
pubmed: 33071792
Ann Hepatol. 2017 Oct 4;16(Suppl. 1: s3-105.):16-21
pubmed: 29118282
J Nutr. 2021 Feb 1;151(2):330-340
pubmed: 33188413