Development of Surgically Transplantable Parathyroid Hormone-Releasing Microbeads.
alginate
hypoparathyroidism
microbeads
parathyroid hormone
tonsil-derived mesenchymal stem cells
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
14 Feb 2022
14 Feb 2022
Historique:
received:
16
12
2021
revised:
09
02
2022
accepted:
12
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Hypoparathyroidism is an endocrine disorder that occurs because of the inability to produce parathyroid hormone (PTH) effectively. Previously, we reported the efficacy of tonsil-derived mesenchymal stem cells (TMSCs) differentiated into parathyroid-like cells for the treatment of hypoparathyroidism. Here, we investigated the feasibility of three-dimensional structural microbeads fabricated with TMSCs and alginate, a natural biodegradable polymer, to treat hypoparathyroidism. Alginate microbeads were fabricated by dropping a 2% (
Identifiants
pubmed: 35203648
pii: biomedicines10020440
doi: 10.3390/biomedicines10020440
pmc: PMC8962264
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research Foundation of Korea
ID : 2018R1D1A1A09083264
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