Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress Induced by Hydrogen Peroxide.
ARPE-19 (human-RPE cell line)
apoptosis
idebenone
mitochondria
nuclear factor erythroid 2-related factor (Nrf2)
oxidative stress
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
21 Feb 2022
21 Feb 2022
Historique:
received:
01
02
2022
revised:
17
02
2022
accepted:
18
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is authorized as a drug for the treatment of Leber's hereditary optic neuropathy. Mitochondria of retinal pigment epithelium (RPE) are particularly vulnerable to oxidative damage associated with cellular senescence. Therefore, the aim of this study was to explore idebenone's cytoprotective effect and its underlying mechanism. We used a human-RPE cell line (ARPE-19) exposed to idebenone pre-treatment for 24 h followed by conditions inducing H
Identifiants
pubmed: 35203712
pii: biomedicines10020503
doi: 10.3390/biomedicines10020503
pmc: PMC8962354
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondi di Ateneo D1: 2020-2021
ID : D1: 2020-2021
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