Single Application of Low-Dose, Hydroxyapatite-Bound BMP-2 or GDF-5 Induces Long-Term Bone Formation and Biomechanical Stabilization of a Bone Defect in a Senile Sheep Lumbar Osteopenia Model.

BMP-2 GDF-5 animal model growth factors osteoinductive osteopenia sheep

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
21 Feb 2022
Historique:
received: 13 01 2022
revised: 11 02 2022
accepted: 14 02 2022
entrez: 25 2 2022
pubmed: 26 2 2022
medline: 26 2 2022
Statut: epublish

Résumé

Effects of hydroxyapatite (HA) particles with bone morphogenetic BMP-2 or GDF-5 were compared in sheep lumbar osteopenia; in vitro release in phosphate-buffered saline (PBS) or sheep serum was assessed by ELISA. Lumbar (L) vertebral bone defects (Ø 3.5 mm) were generated in aged, osteopenic female sheep (

Identifiants

pubmed: 35203721
pii: biomedicines10020513
doi: 10.3390/biomedicines10020513
pmc: PMC8962316
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : German Federal Ministry of Education and Research
ID : 0313177
Organisme : German Federal Ministry of Education and Research
ID : 03577D
Organisme : German Federal Ministry of Education and Research
ID : 0316205B
Organisme : German Federal Ministry of Education and Research
ID : 13N12601

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Auteurs

Ines Hasenbein (I)

Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.
Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.

André Sachse (A)

Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.
Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.

Peter Hortschansky (P)

Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI), 07745 Jena, Germany.

Klaus D Schmuck (KD)

Johnson & Johnson Medical GmbH, DePuySynthes, 22851 Norderstedt, Germany.

Victoria Horbert (V)

Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.
Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.

Christoph Anders (C)

Division of Motor Research, Pathophysiology and Biomechanics, Experimental Trauma Surgery, Department for Hand, Reconstructive, and Trauma Surgery, Jena University Hospital, 07743 Jena, Germany.

Thomas Lehmann (T)

Institute of Medical Statistics, Computer Sciences and Data Sciences, Jena University Hospital, 07743 Jena, Germany.

René Huber (R)

Institute of Clinical Chemistry, Hannover Medical School, 30625 Hannover, Germany.

Alexander Maslaris (A)

Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.

Frank Layher (F)

Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.

Christina Braun (C)

Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.

Andreas Roth (A)

Bereich Endoprothetik/Orthopädie, Klinik für Orthopädie, Unfallchirurgie und Plastische Chirurgie, Uniklinik Leipzig AöR, 04103 Leipzig, Germany.

Frank Plöger (F)

BIOPHARM GmbH, Czernyring 22, 69115 Heidelberg, Germany.

Raimund W Kinne (RW)

Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607 Eisenberg, Germany.

Classifications MeSH