Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM).
anxiety
arousal
fatigue
inferior colliculus
locus coeruleus
midbrain reticular formation
parabrachial complex
periaqueductal gray
postexertional malaise
posttraumatic stress disorder
threat assessment
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
19 Jan 2022
19 Jan 2022
Historique:
received:
22
11
2021
revised:
10
01
2022
accepted:
14
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS and Gulf War Illness (GWI) share features of post-exertional malaise (PEM), exertional exhaustion, or postexertional symptom exacerbation. In a two-day model of PEM, submaximal exercise induced significant changes in activation of the dorsal midbrain during a high cognitive load working memory task (Washington 2020) (Baraniuk this issue). Controls had no net change. However, ME/CFS had increased activity after exercise, while GWI had significantly reduced activity indicating differential responses to exercise and pathological mechanisms. These data plus findings of the midbrain and brainstem atrophy in GWI inspired a review of the anatomy and physiology of the dorsal midbrain and isthmus nuclei in order to infer dysfunctional mechanisms that may contribute to disease pathogenesis and postexertional malaise. The nuclei of the ascending arousal network were addressed. Midbrain and isthmus nuclei participate in threat assessment, awareness, attention, mood, cognition, pain, tenderness, sleep, thermoregulation, light and sound sensitivity, orthostatic symptoms, and autonomic dysfunction and are likely to contribute to the symptoms of postexertional malaise in ME/CFS and GWI.
Identifiants
pubmed: 35203896
pii: brainsci12020132
doi: 10.3390/brainsci12020132
pmc: PMC8870178
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : United States Department of Defense
ID : W81XWH-15-1-0679
Organisme : United States Department of Defense
ID : W81-XWH-09-1-0526
Organisme : NINDS NIH HHS
ID : R21NS088138
Pays : United States
Organisme : NINDS NIH HHS
ID : RO1NS085131
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR000101
Pays : United States
Références
Transl Psychiatry. 2020 Jul 7;10(1):219
pubmed: 32636362
Neuroimage. 2017 Feb 1;146:833-842
pubmed: 27554530
Harv Rev Psychiatry. 2015 Jul-Aug;23(4):263-87
pubmed: 26062169
Cochrane Database Syst Rev. 2021 Nov 24;11:CD004692
pubmed: 34817851
J Neuropsychiatry Clin Neurosci. 2005 Fall;17(4):503-9
pubmed: 16387990
Pharmacol Biochem Behav. 2002 Mar;71(3):481-91
pubmed: 11830182
Am Orthopt J. 2016 Jan;66(1):92-97
pubmed: 27799582
JAMA. 1998 Sep 16;280(11):981-8
pubmed: 9749480
J Transl Med. 2020 Feb 24;18(1):100
pubmed: 32093722
BMC Neurol. 2011 Mar 05;11:30
pubmed: 21375763
Clin Neurophysiol Pract. 2020 Feb 08;5:50-58
pubmed: 32140630
Nat Commun. 2020 Nov 25;11(1):5974
pubmed: 33239627
Otolaryngol Head Neck Surg. 2002 Nov;127(5):387-97
pubmed: 12447232
Behav Neurosci. 1990 Dec;104(6):831-40
pubmed: 2285482
Exp Brain Res. 2017 Sep;235(9):2777-2786
pubmed: 28634886
Magn Reson Med. 2021 Sep;86(3):1674-1686
pubmed: 33949713
J Clin Pathol. 2007 Feb;60(2):117-9
pubmed: 16935963
Behav Brain Res. 1993 Dec 20;58(1-2):49-55
pubmed: 8136049
Croat Med J. 2014 Feb;55(1):27-37
pubmed: 24577824
Prog Brain Res. 2014;209:379-405
pubmed: 24746059
Mol Psychiatry. 2021 Nov;26(11):6773-6788
pubmed: 34131267
Neurosci Biobehav Rev. 2015 Dec;59:83-91
pubmed: 26441374
Biol Psychol. 2007 Feb;74(2):116-43
pubmed: 17049418
Adv Exp Med Biol. 2010;669:353-8
pubmed: 20217381
J Neurosci. 2002 Apr 1;22(7):2748-52
pubmed: 11923440
EBioMedicine. 2017 Dec;26:126-131
pubmed: 29137891
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):
pubmed: 34301891
Front Behav Neurosci. 2019 May 10;13:60
pubmed: 31133827
Appl Med Inform. 2013;33(3):12-21
pubmed: 24415903
Neurosci Biobehav Rev. 2011 Mar;35(4):991-8
pubmed: 21056591
J Transl Med. 2019 Jun 3;17(1):185
pubmed: 31159884
Brain Res Rev. 2009 Apr;60(1):214-25
pubmed: 19146877
J Neurosci. 2004 Nov 24;24(47):10670-8
pubmed: 15564583
Dev Growth Differ. 2016 Jun;58(5):437-45
pubmed: 27273073
Front Neurol. 2019 Jan 10;9:1033
pubmed: 30687207
Eur J Neurosci. 2000 Feb;12(2):689-700
pubmed: 10712649
Brain Behav Immun. 2017 May;62:162-170
pubmed: 28126500
IMA J Math Appl Med Biol. 1996 Sep;13(3):193-205
pubmed: 8921589
Neuroimage Clin. 2019;24:102045
pubmed: 31671321
CNS Spectr. 2004 Sep;9(9):679-85
pubmed: 15337864
Fatigue. 2017;5(4):215-230
pubmed: 30854252
Biol Psychiatry. 2018 Feb 1;83(3):254-262
pubmed: 29100627
J Abnorm Psychol. 1995 Feb;104(1):75-82
pubmed: 7897056
Environ Health Perspect. 2012 Jan;120(1):112-8
pubmed: 21930452
Biol Psychol. 2007 Feb;74(2):301-7
pubmed: 17055142
PLoS One. 2018 Jul 3;13(7):e0200068
pubmed: 29969498
Front Neuroanat. 2019 Feb 27;13:20
pubmed: 30873012
Neuroimage Clin. 2016 Mar 31;11:530-537
pubmed: 27114901
Prog Brain Res. 2008;172:233-64
pubmed: 18772036
Am J Transl Res. 2018 Oct 15;10(10):3254-3264
pubmed: 30416666
Rev Neurosci. 2014;25(5):621-30
pubmed: 24887956
Clin Physiol Funct Imaging. 2006 Mar;26(2):83-6
pubmed: 16494597
J Rheumatol. 2011 Jun;38(6):1113-22
pubmed: 21285161
Am J Med. 1971 Apr;50(4):475-92
pubmed: 4324629
Neuroimage. 2008 Aug 15;42(2):998-1031
pubmed: 18579414
Ann Intern Med. 1994 Dec 15;121(12):953-9
pubmed: 7978722
Stress. 2021 Jul;24(4):370-383
pubmed: 33632072
Neurotoxicology. 2011 Mar;32(2):242-6
pubmed: 21147163
Front Pediatr. 2017 Jun 19;5:121
pubmed: 28674681
Arch Toxicol. 1975 Dec 18;34(4):259-88
pubmed: 766733
Headache. 2010 Feb;50(2):273-89
pubmed: 20039962
Neurotoxicology. 2020 May;78:71-79
pubmed: 32081703
Neural Plast. 2009;2009:462879
pubmed: 19197373
Int J Mol Sci. 2021 Apr 22;22(9):
pubmed: 33922396
Front Neural Circuits. 2018 Dec 21;12:106
pubmed: 30627087
Brain Neurosci Adv. 2020 Jul 21;4:2398212820930321
pubmed: 32954002
Front Physiol. 2013 Jul 24;4:181
pubmed: 23898301
Brain Behav Immun. 2003 Feb;17 Suppl 1:S112-8
pubmed: 12615196
PLoS One. 2013 Jun 14;8(6):e63903
pubmed: 23798990
Neuroimage. 2018 May 1;171:415-436
pubmed: 29278773
Soc Cogn Affect Neurosci. 2013 Aug;8(6):609-16
pubmed: 22446299
NMR Biomed. 2011 Dec;24(10):1302-12
pubmed: 21560176
Cortex. 2016 Jan;74:449-75
pubmed: 26493934
Hum Brain Mapp. 2016 Apr;37(4):1514-30
pubmed: 26821847
Annu Rev Neurosci. 2015 Jul 8;38:433-47
pubmed: 25938726
J Comp Neurol. 2005 Feb 28;483(1):17-29
pubmed: 15672400
Scand Audiol. 1980;9(2):75-82
pubmed: 7444327
Prostaglandins Leukot Essent Fatty Acids. 2018 Dec;139:20-24
pubmed: 30471769
Neuroimage Clin. 2018;20:102-109
pubmed: 30497131
Arthritis Care Res (Hoboken). 2010 May;62(5):600-10
pubmed: 20461783
Front Neuroanat. 2018 Jan 08;11:130
pubmed: 29358907
Hum Brain Mapp. 2019 May;40(7):2033-2051
pubmed: 29091315
Mayo Clin Proc. 2021 Nov;96(11):2861-2878
pubmed: 34454716
Nat Rev Neurosci. 2017 Feb;18(2):73-85
pubmed: 28053327
J Intern Med. 2011 Oct;270(4):327-38
pubmed: 21777306
Science. 1996 Jan 26;271(5248):512-5
pubmed: 8560267
Neurotoxicology. 2015 May;48:239-48
pubmed: 25929683
BMC Neurosci. 2019 Feb 21;20(1):7
pubmed: 30791869
Hear Res. 2016 Jan;331:47-56
pubmed: 26523371
Glob J Health Sci. 2012 Dec 12;5(2):94-110
pubmed: 23445698
Neuroimage. 2012 Mar;60(1):505-22
pubmed: 22197740
Allergy Asthma Proc. 2010 May-Jun;31(3):169-78
pubmed: 20615318
Eur J Neurosci. 2008 Nov;28(9):1877-86
pubmed: 18973601
JAMA Netw Open. 2018 Sep 7;1(5):e182327
pubmed: 30646157
Neuron. 2017 Apr 5;94(1):7-18
pubmed: 28384477
Semin Arthritis Rheum. 2016 Dec;46(3):319-329
pubmed: 27916278
Psychol Rev. 2000 Jul;107(3):411-29
pubmed: 10941275
N Engl J Med. 2013 Apr 11;368(15):1388-97
pubmed: 23574118
Curr Neuropharmacol. 2008 Sep;6(3):254-85
pubmed: 19506724
Pavlov J Biol Sci. 1990 Jul-Sep;25(3):123-9; discussion 129-31
pubmed: 2287525
Front Neuroanat. 2019 Feb 12;13:10
pubmed: 30809133
Neurology. 2015 Nov 17;85(20):1795-805
pubmed: 26475693
J Affect Disord. 2016 Nov 15;205:289-291
pubmed: 27552592
Elife. 2017 Feb 17;6:
pubmed: 28211789
Brain Commun. 2020 Aug 10;2(2):fcaa070
pubmed: 32954325
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):827-53
pubmed: 16563589
Nature. 2016 Jun 01;534(7606):206-12
pubmed: 27279213
Front Psychol. 2018 Aug 17;9:1468
pubmed: 30174633
Science. 2007 Aug 24;317(5841):1079-83
pubmed: 17717184
Neurosci Biobehav Rev. 2017 May;76(Pt A):22-28
pubmed: 28434585
Adv Neurotoxicol. 2020;4:1-78
pubmed: 32518884
Sci Rep. 2020 Apr 1;10(1):5751
pubmed: 32238857
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17101-6
pubmed: 24082116
Magn Reson Imaging. 2014 Apr;32(3):236-40
pubmed: 24468081
Neuropsychol Rev. 2012 Jun;22(2):170-80
pubmed: 22577003
J Neuropathol Exp Neurol. 2012 Jun;71(6):531-46
pubmed: 22592840
Front Neurosci. 2021 Dec 15;15:748426
pubmed: 34975370
Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):
pubmed: 34330840
Annu Rev Physiol. 2019 Feb 10;81:285-308
pubmed: 30256726
Horm Behav. 2011 Sep;60(4):448-56
pubmed: 21820440
PLoS One. 2018 Oct 15;13(10):e0205393
pubmed: 30321200
Int J Occup Med Environ Health. 2019 Jul 15;32(4):503–526
pubmed: 31309787
Brain Behav. 2016 Sep 20;6(12):e00579
pubmed: 28032002
J Neurosci. 2019 Oct 16;39(42):8225-8230
pubmed: 31619491
J Psychopharmacol. 2013 Dec;27(12):1090-106
pubmed: 23704363
Clin Physiol Funct Imaging. 2008 Nov;28(6):364-72
pubmed: 18671793
Brain Commun. 2020;2(1):fcz039
pubmed: 32025659
Trends Neurosci. 2018 May;41(5):280-293
pubmed: 29703377
JCI Insight. 2016 Dec 22;1(21):e89376
pubmed: 28018972
Am J Epidemiol. 2000 Nov 15;152(10):992-1002
pubmed: 11092441
Front Syst Neurosci. 2020 Dec 11;14:606345
pubmed: 33362482
Neuroimage. 2019 Jan 1;184:293-316
pubmed: 30179717
Rev Infect Dis. 1991 Jan-Feb;13 Suppl 1:S39-44
pubmed: 1850542
J Transl Med. 2020 Sep 1;18(1):335
pubmed: 32873297
Sci Rep. 2019 Mar 12;9(1):4240
pubmed: 30862811
Brain Sci. 2019 Mar 18;9(3):
pubmed: 30889866
Nat Rev Neurol. 2018 Jun;14(6):338-350
pubmed: 29691490