Cognitive Impairment in Anti-Phospholipid Syndrome and Anti-Phospholipid Antibody Carriers.
anti-phospholipid carrier
anti-phospholipid syndrome
cognitive impairment
dementia
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
05 Feb 2022
05 Feb 2022
Historique:
received:
27
11
2021
revised:
27
01
2022
accepted:
02
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Cognitive impairment is frequently reported among anti-phospholipid syndrome (APS) patients as well as anti-phospholipid antibody (aPL) carriers, but it is less studied than other manifestations of this condition. Moreover, the exact prevalence of cognitive impairment in these patients has not been accurately determined, mainly due to inconsistency in the tools used to identify impairment, small sample sizes, and variability in the anti-phospholipid antibodies measured and positivity cutoffs. The notion of a direct pathogenic effect is supported by the observation that the higher the number of aPLs present and the higher the load of the specific antibody, the greater the risk of cognitive impairment. There is some evidence to suggest that besides the thrombotic process, inflammation-related pathways play a role in the pathogenesis of cognitive impairment in APS. The cornerstone treatments of APS are anti-coagulant and anti-thrombotic medications. These treatments have shown some favorable effects in reversing cognitive impairment, but solid evidence for the efficacy and safety of these treatments in the context of cognitive impairment is still lacking. In this article, we review the current knowledge regarding the epidemiology, pathophysiology, clinical associations, and treatment of cognitive impairment associated with APS and aPL positivity.
Identifiants
pubmed: 35203985
pii: brainsci12020222
doi: 10.3390/brainsci12020222
pmc: PMC8870021
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NICHD NIH HHS
ID : P50 HD105352
Pays : United States
Références
Intern Med. 1992 Oct;31(10):1169-74
pubmed: 1286221
Exp Clin Immunogenet. 1992;9(2):72-9
pubmed: 1489552
Arthritis Rheum. 2007 Dec 15;57(8):1461-72
pubmed: 18050188
Lupus. 2018 Apr;27(4):665-669
pubmed: 29050535
J Clin Exp Neuropsychol. 1999 Apr;21(2):251-64
pubmed: 10425522
Arthritis Rheumatol. 2019 Feb;71(2):290-301
pubmed: 30152151
Neurology. 1996 Jun;46(6):1599-603
pubmed: 8649556
Curr Rheumatol Rep. 2016 Feb;18(2):11
pubmed: 26923254
J Int Neuropsychol Soc. 1997 Jul;3(4):377-86
pubmed: 9260447
Clin Neuropsychol. 2019 Feb;33(2):200-208
pubmed: 30608020
Neurology. 2003 Jul 8;61(1):108-10
pubmed: 12847168
Neuroepidemiology. 2013;40(2):73-84
pubmed: 23095514
Arthritis Care Res (Hoboken). 2022 Feb;74(2):324-335
pubmed: 32986935
Lupus. 1995 Dec;4(6):482-5
pubmed: 8749572
Rheumatology (Oxford). 2003 Feb;42(2):200-13
pubmed: 12595612
Arthritis Care Res (Hoboken). 2016 Nov;68(11):1655-1663
pubmed: 26946337
Curr Rheumatol Rep. 2020 Jul 22;22(9):51
pubmed: 32699944
J Rheumatol. 2000 Dec;27(12):2817-21
pubmed: 11128669
Curr Rheumatol Rep. 2012 Feb;14(1):95-8
pubmed: 22134844
Neuropathol Appl Neurobiol. 2015 Aug;41(5):657-71
pubmed: 25201289
Clin Rheumatol. 2019 Nov;38(11):3129-3137
pubmed: 31367942
J Neuroimmunol. 2014 Jul 15;272(1-2):10-5
pubmed: 24837568
Lupus. 2003;12(6):436-42
pubmed: 12873044
Clin Exp Rheumatol. 2014 Jan-Feb;32(1):34-40
pubmed: 24021640
Lupus. 2011 Feb;20(2):206-18
pubmed: 21303837
Iran J Neurol. 2013;12(4):172-5
pubmed: 24250929
Cochrane Database Syst Rev. 2021 Nov 23;11:CD001919
pubmed: 34813082
Rheumatology (Oxford). 2021 Jan 5;60(1):179-187
pubmed: 32613245
J Neurol Sci. 2002 Nov 15;203-204:81-4
pubmed: 12417362
G Ital Dermatol Venereol. 2019 Jun;154(3):277-285
pubmed: 30375212
Postgrad Med J. 2003 Feb;79(928):81-3
pubmed: 12612321
Lupus. 2015 Jul;24(8):875-9
pubmed: 25697771
Lupus. 2001;10(7):496-9
pubmed: 11480848
Rheumatology (Oxford). 2021 Dec 24;61(1):24-41
pubmed: 34003972
Arthritis Rheum. 2002 Apr;46(4):1019-27
pubmed: 11953980
Neurology. 2005 Jan 25;64(2):297-303
pubmed: 15668428
Brain Sci. 2022 Jan 11;12(1):
pubmed: 35053834
Arthritis Rheum. 2005 May;52(5):1473-80
pubmed: 15880829
Dement Neuropsychol. 2018 Apr-Jun;12(2):143-151
pubmed: 29988333
Hematology Am Soc Hematol Educ Program. 2013;2013:675-80
pubmed: 24319251
Semin Thromb Hemost. 2021 Jul;47(5):506-511
pubmed: 33878780
Rheumatology (Oxford). 2004 Dec;43(12):1555-60
pubmed: 15342927
Arthritis Care Res (Hoboken). 2012 Sep;64(9):1328-33
pubmed: 22549897
Arch Intern Med. 2006 Nov 13;166(20):2278-84
pubmed: 17101948
Clin Exp Rheumatol. 2021 May-Jun;39(3):555-563
pubmed: 32828148
PLoS One. 2018 May 3;13(5):e0196103
pubmed: 29723209
Rheumatology (Oxford). 2021 Apr 6;60(4):1774-1783
pubmed: 33099642
J Rheumatol. 2004 Nov;31(11):2156-62
pubmed: 15517627
J Rheumatol. 2003 May;30(5):985-92
pubmed: 12734893
J Clin Invest. 1997 Aug 1;100(3):613-9
pubmed: 9239409
Semin Arthritis Rheum. 2012 Oct;42(2):179-85
pubmed: 22595642
Lupus. 2010 Apr;19(5):613-9
pubmed: 19934177
Ann Rheum Dis. 2019 Feb;78(2):279-282
pubmed: 30185414
PLoS One. 2012;7(3):e33824
pubmed: 22461897
Arthritis Rheum. 2013 Feb;65(2):464-71
pubmed: 23124321
Ann Rheum Dis. 2019 Oct;78(10):1296-1304
pubmed: 31092409
J Alzheimers Dis. 2019;69(2):561-576
pubmed: 31104025
Autoimmun Rev. 2016 Dec;15(12):1193-1198
pubmed: 27639839
Rheumatology (Oxford). 2005 Jan;44(1):95-9
pubmed: 15367749
Arthritis Rheum. 1999 Apr;42(4):728-34
pubmed: 10211887
JAMA Intern Med. 2015 Sep;175(9):1450-8
pubmed: 26052687
Arthritis Rheum. 1999 Apr;42(4):735-41
pubmed: 10211888
Stroke. 1995 May;26(5):749-54
pubmed: 7740561
Dement Geriatr Cogn Disord. 2000 Jan-Feb;11(1):36-8
pubmed: 10629360