Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the

Parkinson’s disease aged dopamine inflammaging inflammation neuroinflammation oxidative stress renin–angiotensin system

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
08 Feb 2022
Historique:
received: 29 12 2021
revised: 31 01 2022
accepted: 05 02 2022
entrez: 25 2 2022
pubmed: 26 2 2022
medline: 26 2 2022
Statut: epublish

Résumé

The tissue renin-angiotensin system (RAS) has been shown to be involved in prooxidative and proinflammatory changes observed in aging and aging-related diseases such as dopaminergic degeneration in Parkinson's disease (PD). We studied the activation of the NLRP3 inflammasome in the

Identifiants

pubmed: 35204211
pii: antiox11020329
doi: 10.3390/antiox11020329
pmc: PMC8868290
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministry of Economy, Industry and Competitiveness
ID : RTI2018-098830-B-I00
Organisme : Instituto de Salud Carlos III
ID : PI20/00345
Organisme : Instituto de Salud Carlos III
ID : RD16/0011/0016
Organisme : Consellería de Cultura, Educación e Ordenación Universitaria
ID : ED431C 2018/10
Organisme : Consellería de Cultura, Educación e Ordenación Universitaria
ID : ED431G/05

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Auteurs

Aloia Quijano (A)

Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Department of Morphological Sciences, IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Carmen Diaz-Ruiz (C)

Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Department of Morphological Sciences, IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Networking Research Center on Neurodegenerative Diseases (CiberNed), 28031 Madrid, Spain.

Andrea Lopez-Lopez (A)

Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Department of Morphological Sciences, IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Networking Research Center on Neurodegenerative Diseases (CiberNed), 28031 Madrid, Spain.

Begoña Villar-Cheda (B)

Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Department of Morphological Sciences, IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Networking Research Center on Neurodegenerative Diseases (CiberNed), 28031 Madrid, Spain.

Ana Muñoz (A)

Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Department of Morphological Sciences, IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Networking Research Center on Neurodegenerative Diseases (CiberNed), 28031 Madrid, Spain.

Ana I Rodriguez-Perez (AI)

Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Department of Morphological Sciences, IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Networking Research Center on Neurodegenerative Diseases (CiberNed), 28031 Madrid, Spain.

Jose L Labandeira-Garcia (JL)

Laboratory of Cellular and Molecular Neurobiology of Parkinson's Disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Department of Morphological Sciences, IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Networking Research Center on Neurodegenerative Diseases (CiberNed), 28031 Madrid, Spain.

Classifications MeSH