Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells.
D-amino acid oxidase
RNAseq
endothelial cells
metabolomics
reactive oxygen species
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
21 Feb 2022
21 Feb 2022
Historique:
received:
01
02
2022
revised:
15
02
2022
accepted:
17
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Reactive oxygen species (ROS) are important mediators of both physiological and pathophysiological signal transduction in the cardiovascular system. The effects of ROS on cellular processes depend on the concentration, localization, and duration of exposure. Cellular stress response mechanisms have evolved to mitigate the negative effects of acute oxidative stress. In this study, we investigate the short-term and long-term metabolic and transcriptomic response of human umbilical vein endothelial cells (HUVEC) to different types and concentrations of ROS. To generate intracellular H
Identifiants
pubmed: 35204316
pii: antiox11020434
doi: 10.3390/antiox11020434
pmc: PMC8869421
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : RE 4360/2-1
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB815
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB834/3
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1039
Organisme : Excellent Cluster Cardio-Pulmonary Institute
ID : EXS2026
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