Diagnostic Efficacy of Rectal Suction Biopsy with Regard to Weight in Children Investigated for Hirschsprung's Disease.
Hirschsprung’s disease
children
rectal suction biopsy
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
18 Jan 2022
18 Jan 2022
Historique:
received:
07
12
2021
revised:
09
01
2022
accepted:
13
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Diagnostic efficacy, defined as the percentage of rectal suction biopsy (RSB) specimens sufficient enough to determine the absence of ganglia cells in Hirschsprung's disease (HD) diagnosis, has been reported to be low, requiring repeated biopsies. The aim was to explore whether RSB diagnostic efficacy was influenced by the child's weight and to ascertain whether RSB efficacy differed between aganglionic and ganglionic tissue. Efficacy analyses were conducted in a national HD-center's register on children 0-15 kg, examined between 2011-2019. First-time RSB diagnostic efficacy was correlated to the children's weight and final HD diagnosis. Among the 84 children who had first-time RSB, the overall diagnostic efficacy was 85% (71/84). The efficacy was higher among children weighing less than the identified cut-off of 9.0 kg (89% in 0-9.0 kg versus 62% in 9.01-15.0 kg, The RSB diagnostic efficacy was significantly higher in children weighing less than 9.0 kg and was less in aganglionic compared to ganglionic tissue. Therefore, weight can be useful to predict RSB diagnostic efficacy.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Diagnostic efficacy, defined as the percentage of rectal suction biopsy (RSB) specimens sufficient enough to determine the absence of ganglia cells in Hirschsprung's disease (HD) diagnosis, has been reported to be low, requiring repeated biopsies. The aim was to explore whether RSB diagnostic efficacy was influenced by the child's weight and to ascertain whether RSB efficacy differed between aganglionic and ganglionic tissue.
MATERIALS AND METHODS
METHODS
Efficacy analyses were conducted in a national HD-center's register on children 0-15 kg, examined between 2011-2019. First-time RSB diagnostic efficacy was correlated to the children's weight and final HD diagnosis.
RESULTS
RESULTS
Among the 84 children who had first-time RSB, the overall diagnostic efficacy was 85% (71/84). The efficacy was higher among children weighing less than the identified cut-off of 9.0 kg (89% in 0-9.0 kg versus 62% in 9.01-15.0 kg,
CONCLUSIONS
CONCLUSIONS
The RSB diagnostic efficacy was significantly higher in children weighing less than 9.0 kg and was less in aganglionic compared to ganglionic tissue. Therefore, weight can be useful to predict RSB diagnostic efficacy.
Identifiants
pubmed: 35204845
pii: children9020124
doi: 10.3390/children9020124
pmc: PMC8870311
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Pediatr Gastroenterol Nutr. 2006 May;42(5):496-505
pubmed: 16707970
Eur J Pediatr Surg. 2019 Oct;29(5):425-430
pubmed: 30068006
Semin Pediatr Surg. 2009 Nov;18(4):212-23
pubmed: 19782303
Ann Surg. 2004 Aug;240(2):205-13
pubmed: 15273542
J Pediatr Surg. 2009 Feb;44(2):395-8
pubmed: 19231542
J Pediatr Gastroenterol Nutr. 2007 Feb;44(2):198-202
pubmed: 17255831
Pediatr Surg Int. 2003 Aug;19(6):439-42
pubmed: 12698267
Pediatr Surg Int. 1998 Mar;13(2-3):121-4
pubmed: 9563023
N Engl J Med. 1965 May 13;272:990-3
pubmed: 14279253
J Pediatr Surg. 2005 Oct;40(10):1527-31
pubmed: 16226977
J Surg Res. 2016 Mar;201(1):149-55
pubmed: 26850196
Clin Gastroenterol Hepatol. 2015 Oct;13(10):1801-7
pubmed: 26027547
Nat Rev Neurosci. 2007 Jun;8(6):466-79
pubmed: 17514199
J Pediatr Surg. 2020 Jan;55(1):67-70
pubmed: 31677826
Pediatr Surg Int. 2015 Sep;31(9):821-30
pubmed: 26156878
Pediatr Surg Int. 2016 Aug;32(8):717-22
pubmed: 27350541
J Pediatr Surg. 2016 Jun;51(6):966-9
pubmed: 27032614
J Pediatr Surg. 2006 Jun;41(6):1043-8
pubmed: 16769331
Pediatr Radiol. 2013 Aug;43(8):950-7
pubmed: 23463159