Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact.
colon cancer
discoidin domain receptor
event free survival
prognosis
survival
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Feb 2022
13 Feb 2022
Historique:
received:
29
12
2021
revised:
28
01
2022
accepted:
10
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Extracellular matrix components such as collagens are deposited within the tumor microenvironment at primary and metastatic sites and are recognized to be critical during tumor progression and metastasis development. This study aimed to evaluate the clinical and prognostic impact of Discoidin Domain Receptor 1 (DDR1) expression in colon cancers and its association with a particular molecular and/or morphological profile and to evaluate its potential role as a prognosis biomarker. Immunohistochemical expression of DDR1 was evaluated on 292 colonic adenocarcinomas. DDR1 was highly expressed in 240 (82.2%) adenocarcinomas. High DDR1 immunostaining score was significantly associated, on univariate analysis, with male sex, left tumor location,
Identifiants
pubmed: 35205677
pii: cancers14040928
doi: 10.3390/cancers14040928
pmc: PMC8869771
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ligue Nationale Contre le Cancer
ID : 61/2014/KM/ML/Recherche and 2015/KM/NM/PFRS/232
Organisme : Centre Hospitalier Universitaire de Reims
ID : AU14-03 and AOL 2015-11
Organisme : SFR CAP SANTE URCA
ID : AAP 2018
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