Protein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells.
E3 ubiquitin ligases
cancer stem cells
post-translational modification
protein degradation
ubiquitination
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Feb 2022
16 Feb 2022
Historique:
received:
30
12
2021
revised:
09
02
2022
accepted:
11
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Cancer stem cells are a small subpopulation within the tumor with high capacity for self-renewal, differentiation and reconstitution of tumor heterogeneity. Cancer stem cells are major contributors of tumor initiation, metastasis and therapy resistance in cancer. Emerging evidence indicates that ubiquitination-mediated post-translational modification plays a fundamental role in the maintenance of cancer stem cell characteristics. In this review, we will discuss how protein degradation controlled by the E3 ubiquitin ligases plays a fundamental role in the self-renewal, maintenance and differentiation of cancer stem cells, highlighting the possibility to develop novel therapeutic strategies against E3 ubiquitin ligases targeting CSCs to fight cancer.
Identifiants
pubmed: 35205738
pii: cancers14040990
doi: 10.3390/cancers14040990
pmc: PMC8870109
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI18/00121 and PI21/00238
Organisme : "la Caixa" Foundation
ID : LCF/TR/CI19/52460016 and LCF/TR/CC21/52490003
Organisme : Axencia Galega de Innovacion
ID : IN607B2020/14
Organisme : Fundación Científica AECC/AECC
ID : PRDLC21591RODR
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