Comparison of Antimycotic Activity of Originator and Generics of Voriconazole and Anidulafungin against Clinical Isolates of
C. albicans
C. glabrata
MIC
TKC
antifungals
generic
innovator
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
17 Feb 2022
17 Feb 2022
Historique:
received:
25
01
2022
revised:
15
02
2022
accepted:
16
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Concerns have been expressed about the interchangeability of innovator and generic antifungals in their activity and chemical stability. The activity of two different antimycotics was tested, each with one originator and two generics. For voriconazole, the originator VFEND MIC results showed no significant difference in activity of generic and innovator antimycotic in all settings, which was also confirmed by TKC. Stability testing revealed no differences between originator and generic drugs. The present study demonstrates the interchangeability of generic and originator antimycotic in-vitro, potentially leading to broader public acceptance for generic antimycotics.
Sections du résumé
BACKGROUND
BACKGROUND
Concerns have been expressed about the interchangeability of innovator and generic antifungals in their activity and chemical stability.
MATERIALS/METHODS
METHODS
The activity of two different antimycotics was tested, each with one originator and two generics. For voriconazole, the originator VFEND
RESULTS
RESULTS
MIC results showed no significant difference in activity of generic and innovator antimycotic in all settings, which was also confirmed by TKC. Stability testing revealed no differences between originator and generic drugs.
CONCLUSIONS
CONCLUSIONS
The present study demonstrates the interchangeability of generic and originator antimycotic in-vitro, potentially leading to broader public acceptance for generic antimycotics.
Identifiants
pubmed: 35205949
pii: jof8020195
doi: 10.3390/jof8020195
pmc: PMC8879245
pii:
doi:
Types de publication
Journal Article
Langues
eng
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