Cholestatic Liver Disease and Pregnancy: A Systematic Review and Meta-Analysis.
cholestatic liver diseases
fetal complications
maternal complications
pregnancy
primary biliary cholangitis
primary sclerosing cholangitis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
18 Feb 2022
18 Feb 2022
Historique:
received:
21
01
2022
revised:
08
02
2022
accepted:
16
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are two types of chronic cholestatic liver disease (CCLD). Little is known regarding the relationship between these conditions and pregnancy. We performed a systematic review and meta-analysis regarding the maternal and fetal outcomes amongst patients with a known diagnosis of PBC and PSC undergoing pregnancy. Our analysis shows that patients with PBC and PSC who undergo pregnancy are at an increased risk of pre-term delivery, as well as the development of new or worsening pruritus during pregnancy. Additionally, patients with PBC are at higher risk of undergoing a biochemical disease flare during the postpartum period compared to during pregnancy. However, there were no documented cases of maternal mortality or development of decompensated cirrhosis during pregnancy or the postpartum period.
Identifiants
pubmed: 35207342
pii: jcm11041068
doi: 10.3390/jcm11041068
pmc: PMC8875982
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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