Antigen-Presenting Cells in Psoriasis.
antigen-presenting cells
autoantigens
keratinocyte
mast cell
neuropeptide
psoriasis
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
03 Feb 2022
03 Feb 2022
Historique:
received:
03
01
2022
revised:
27
01
2022
accepted:
31
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset.
Identifiants
pubmed: 35207521
pii: life12020234
doi: 10.3390/life12020234
pmc: PMC8880330
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research, Development and Innovation Office
ID : FK134588, K123975, FK134993, GINOP-2.3.2-15-2016-00006
Organisme : Ministry for Innovation and Technology
ID : TKP2020-IKA-04
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