Ion Channel Involvement in Tumor Drug Resistance.
cancer
chemotherapeutics
drug resistance
ion channel
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
03 Feb 2022
03 Feb 2022
Historique:
received:
24
11
2021
revised:
28
01
2022
accepted:
02
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Over 90% of deaths in cancer patients are attributed to tumor drug resistance. Resistance to therapeutic agents can be due to an innate property of cancer cells or can be acquired during chemotherapy. In recent years, it has become increasingly clear that regulation of membrane ion channels is an important mechanism in the development of chemoresistance. Here, we review the contribution of ion channels in drug resistance of various types of cancers, evaluating their potential in clinical management. Several molecular mechanisms have been proposed, including evasion of apoptosis, cell cycle arrest, decreased drug accumulation in cancer cells, and activation of alternative escape pathways such as autophagy. Each of these mechanisms leads to a reduction of the therapeutic efficacy of administered drugs, causing more difficulty in cancer treatment. Thus, targeting ion channels might represent a good option for adjuvant therapies in order to counteract chemoresistance development.
Identifiants
pubmed: 35207698
pii: jpm12020210
doi: 10.3390/jpm12020210
pmc: PMC8878471
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministry of Education, Universities and Research
ID : 20174TB8KW_002
Organisme : Ministry of Education, Universities and Research
ID : 20174TB8KW_003
Organisme : Italian Association for Cancer Research
ID : #IG 21558
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