Intra- and Early Postoperative Evaluation of Malperfused Areas in an Irradiated Random Pattern Skin Flap Model Using Indocyanine Green Angiography and Near-Infrared Reflectance-Based Imaging and Infrared Thermography.
imaging
irradiation
malperfusion
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
08 Feb 2022
08 Feb 2022
Historique:
received:
17
11
2021
revised:
18
01
2022
accepted:
27
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Assessment of tissue perfusion after irradiation of random pattern flaps still remains a challenge. Twenty-five rats received harvesting of bilateral random pattern fasciocutaneous flaps. Group 1 served as nonirradiated control group. The right flaps of the groups 2-5 were irradiated with 20 Gy postoperatively (group 2), 3 × 12 Gy postoperatively (group 3), 20 Gy preoperatively (group 4) and 3 × 12 Gy preoperatively (group 5). Imaging with infrared thermography, indocyanine green angiography and near-infrared reflectance-based imaging were performed to detect necrotic areas of the flaps. Analysis of the percentage of the necrotic area of the irradiated flaps showed a statistically significant increase from day 1 to 14 only in group 5 ( Indocyanine green angiography is more precise in prediction of necrotic areas in random pattern skin flaps when compared to hyperspectral imaging, thermography or clinical impression. Preoperative fractional irradiation with a lower individual dose but a higher total dose has a more negative impact on flap perfusion compared to higher single stage irradiation.
Sections du résumé
BACKGROUND
BACKGROUND
Assessment of tissue perfusion after irradiation of random pattern flaps still remains a challenge.
METHODS
METHODS
Twenty-five rats received harvesting of bilateral random pattern fasciocutaneous flaps. Group 1 served as nonirradiated control group. The right flaps of the groups 2-5 were irradiated with 20 Gy postoperatively (group 2), 3 × 12 Gy postoperatively (group 3), 20 Gy preoperatively (group 4) and 3 × 12 Gy preoperatively (group 5). Imaging with infrared thermography, indocyanine green angiography and near-infrared reflectance-based imaging were performed to detect necrotic areas of the flaps.
RESULTS
RESULTS
Analysis of the percentage of the necrotic area of the irradiated flaps showed a statistically significant increase from day 1 to 14 only in group 5 (
CONCLUSION
CONCLUSIONS
Indocyanine green angiography is more precise in prediction of necrotic areas in random pattern skin flaps when compared to hyperspectral imaging, thermography or clinical impression. Preoperative fractional irradiation with a lower individual dose but a higher total dose has a more negative impact on flap perfusion compared to higher single stage irradiation.
Identifiants
pubmed: 35207725
pii: jpm12020237
doi: 10.3390/jpm12020237
pmc: PMC8880010
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Chirurg. 2021 Dec;92(12):1159-1170
pubmed: 33904942
Plast Reconstr Surg. 1974 Nov;54(5):585-98
pubmed: 4608902
Clin Podiatr Med Surg. 2018 Jul;35(3):343-355
pubmed: 29861017
Ann Plast Surg. 2015 Jul;75(1):102-7
pubmed: 24401807
J Oral Maxillofac Surg. 1984 Jul;42(7):447-52
pubmed: 6376735
Invest Radiol. 2009 Aug;44(8):440-6
pubmed: 19448553
J Vasc Res. 2010;47(6):472-80
pubmed: 20431296
J Exp Med. 2005 Sep 19;202(6):739-50
pubmed: 16157686
J Trauma Acute Care Surg. 2012 Mar;72(3):744-50
pubmed: 22491564
Front Oncol. 2020 May 13;10:719
pubmed: 32477947
J Biomed Opt. 2012 Feb;17(2):026010
pubmed: 22463042
Ann Plast Surg. 2015 Mar;74(3):365-70
pubmed: 23788152
Handchir Mikrochir Plast Chir. 2019 Dec;51(6):410-417
pubmed: 31698484
Int J Radiat Oncol Biol Phys. 2000 May 1;47(2):277-90
pubmed: 10802350
Plast Reconstr Surg. 2012 May;129(5):1043-1048
pubmed: 22544087
Clin Hemorheol Microcirc. 2009;43(1-2):11-8
pubmed: 22614826
Plast Reconstr Surg. 2016 May;137(5):1486-1497
pubmed: 27119923
World J Surg. 2021 Jan;45(1):132-140
pubmed: 32995931
Int Wound J. 2021 Dec;18(6):932-939
pubmed: 34128314
Scand J Plast Reconstr Surg Hand Surg. 2002;36(5):257-61
pubmed: 12477082
Int J Radiat Oncol Biol Phys. 1995 Oct 15;33(3):627-33
pubmed: 7558952
J Pathol. 2020 Apr;250(5):647-655
pubmed: 31990369
Biomed Rep. 2018 Apr;8(4):330-334
pubmed: 29541454
Ann Plast Surg. 2005 Aug;55(2):117-21
pubmed: 16034237
Br J Plast Surg. 2005 Jul;58(5):695-701
pubmed: 15925341
Infrared Phys Technol. 2012 Jul;55(4):221-235
pubmed: 32288544
Plast Reconstr Surg. 2009 Apr;123(4):1187-1197
pubmed: 19337087
Ann Plast Surg. 2019 Oct;83(4S Suppl 1):S59-S64
pubmed: 31513068
JAMA Facial Plast Surg. 2013 Sep-Oct;15(5):344-8
pubmed: 23787778
Radiother Oncol. 2010 Oct;97(1):149-61
pubmed: 20888056
Wound Repair Regen. 2019 Jan;27(1):39-48
pubmed: 30338888
Plast Reconstr Surg. 2001 Apr 15;107(5):1190-7; discussion 1198-200
pubmed: 11373560
Cardiovasc Intervent Radiol. 2017 Aug;40(8):1131-1140
pubmed: 28497187
Arch Orthop Trauma Surg. 2021 Jan;141(1):165-171
pubmed: 33130937
Plast Reconstr Surg. 2017 Jun;139(6):1285e-1290e
pubmed: 28538567
Plast Reconstr Surg. 2011 Feb;127(2):560-568
pubmed: 21285760
Cardiovasc Res. 2017 Jun 1;113(7):783-794
pubmed: 28444128
Int J Radiat Oncol Biol Phys. 2001 May 1;50(1):213-20
pubmed: 11316566
Plast Reconstr Surg. 1999 Dec;104(7):2079-91
pubmed: 11149772