Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity.
amino acid
arterial
cord
energy
metabolism
metabolomics
parity
plasma
umbilical
venous
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
13 Feb 2022
13 Feb 2022
Historique:
received:
21
12
2021
revised:
01
02
2022
accepted:
09
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Umbilical cord blood is frequently used in health monitoring of the neonate. Results may be affected by the proportion of arterial and venous cord blood, the venous blood coming from the mother to supply oxygen and nutrients to the infant, and the arterial carrying waste products from the fetus. Here, we sampled arterial and venous umbilical cords separately from 48 newly delivered infants and examined plasma metabolomes using GC-MS/MS metabolomics. We investigated differences in metabolomes between arterial and venous blood and their associations with gestational length, birth weight, sex, and whether the baby was the first born or not, as well as maternal age and BMI. Using multilevel random forest analysis, a classification rate of 79% was achieved for arteriovenous differences (
Identifiants
pubmed: 35208249
pii: metabo12020175
doi: 10.3390/metabo12020175
pmc: PMC8877791
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swedish Research Council
ID : 521-2013-3154
Organisme : Swedish Research Council
ID : 2019-0137
Organisme : Västra Götaland Regional Council
ID : 612-0618-15
Organisme : Jane och Dan Olssons stiftelse
ID : 2020-23
Organisme : Royal Society of Sciences and Letters in Gothenburg
ID : 2018-250
Organisme : Stiftelsen Längmanska Kulturfonden
ID : BA190755
Organisme : Swedish Research Council for Health Working Life and Welfare
ID : 2018-00485
Organisme : Innovation unit at region Norrbotten
ID : N/A
Références
Paediatr Perinat Epidemiol. 2004 Sep;18(5):377-84
pubmed: 15367325
Mol Biosyst. 2015 Sep;11(9):2483-92
pubmed: 26140445
Early Hum Dev. 2013 May;89(5):315-20
pubmed: 23178109
Acta Diabetol. 2019 Apr;56(4):421-430
pubmed: 30725264
J Proteome Res. 2016 Jan 4;15(1):259-65
pubmed: 26615962
PLoS One. 2012;7(12):e50520
pubmed: 23227182
Diabetes. 2013 Nov;62(11):3951-6
pubmed: 23929934
Metabolomics. 2016;12(11):173
pubmed: 27746707
Pediatr Res. 1985 Jul;19(7):700-6
pubmed: 3927251
Annu Rev Nutr. 1992;12:183-206
pubmed: 1503803
Eur J Popul. 2018 Feb 21;35(1):63-85
pubmed: 30976268
Arch Dis Child Fetal Neonatal Ed. 2007 Nov;92(6):F430-4
pubmed: 17951550
Anal Bioanal Chem. 2012 Jan;402(3):1109-21
pubmed: 22101423
Obes Facts. 2017;10(2):85-100
pubmed: 28376503
Sci Rep. 2020 Aug 26;10(1):14209
pubmed: 32848180
J Perinat Med. 2016 Aug 1;44(6):695-704
pubmed: 26756086
J Clin Endocrinol Metab. 2000 May;85(5):1828-33
pubmed: 10843160
Am J Epidemiol. 1997 Jul 15;146(2):161-70
pubmed: 9230778
J Proteome Res. 2008 Oct;7(10):4483-91
pubmed: 18754629
Am J Obstet Gynecol. 2002 Feb;186(2):274-8
pubmed: 11854649
J Proteome Res. 2018 Mar 2;17(3):1235-1247
pubmed: 29401400
J Clin Endocrinol Metab. 2019 Oct 1;104(10):4459-4472
pubmed: 31498869
BMJ Open. 2018 Oct 21;8(10):e022013
pubmed: 30344169
Eur J Prev Cardiol. 2019 Apr;26(6):592-602
pubmed: 30567461
J Steroid Biochem Mol Biol. 2010 Aug;121(3-5):594-610
pubmed: 19897033
Nucleic Acids Res. 2021 Jul 2;49(W1):W388-W396
pubmed: 34019663
Diabetes Care. 2017 Jul;40(7):902-910
pubmed: 28637888
PLoS One. 2013 Dec 02;8(12):e80121
pubmed: 24312458
Paediatr Perinat Epidemiol. 2007 Nov;21(6):541-9
pubmed: 17937740
Indian Pediatr. 2005 Oct;42(10):1029-32
pubmed: 16269841
Am J Epidemiol. 2006 Jun 1;163(11):1035-41
pubmed: 16641310
Metabolites. 2019 Jul 25;9(8):
pubmed: 31349624
Pediatr Res. 2001 Feb;49(2):141-7
pubmed: 11158505
Anal Chem. 2005 Sep 1;77(17):5635-42
pubmed: 16131076
J Transl Med. 2012 Jul 09;10:142
pubmed: 22776444
Bioinformatics. 2019 Mar 15;35(6):972-980
pubmed: 30165467
Thromb Res. 2004;114(5-6):397-407
pubmed: 15507270
Nat Methods. 2018 Jan;15(1):53-56
pubmed: 29176591
Environ Int. 2012 Nov 1;48:1-8
pubmed: 22820015
J Proteome Res. 2013 Jun 7;12(6):2764-78
pubmed: 23527880
Metabolism. 2017 Nov;76:11-22
pubmed: 28987236
PLoS One. 2021 Jan 25;16(1):e0242978
pubmed: 33493154
PLoS One. 2017 Oct 5;12(10):e0185760
pubmed: 28982184
Birth. 2006 Mar;33(1):12-7
pubmed: 16499527