Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening.
drug carrier
drug development
drug toxicity screening
micro/nanoparticles
microfluidic technology
organs-on-chips
Journal
Micromachines
ISSN: 2072-666X
Titre abrégé: Micromachines (Basel)
Pays: Switzerland
ID NLM: 101640903
Informations de publication
Date de publication:
27 Jan 2022
27 Jan 2022
Historique:
received:
31
12
2021
revised:
23
01
2022
accepted:
23
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Microfluidic technology has been highly useful in nanovolume sample preparation, separation, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.
Identifiants
pubmed: 35208324
pii: mi13020200
doi: 10.3390/mi13020200
pmc: PMC8877367
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Integration Project of Science, Education and Industry in Qilu University of Technology (Shandong Academy of Sciences)
ID : 2020KJC-YJ04 and -YJ03
Organisme : Provincial key R&D project
ID : 2021CXGC010515
Organisme : the international S&T cooperation program of Shandong Academy of Sciences
ID : 2019GHPY06
Organisme : the Double Hundred Plan of Shandong Province
ID : WST2017001
Organisme : the Pilot Project Scheme of Shandong Academy of Sciences
ID : 2013-2018
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