HELLP Syndrome-Holistic Insight into Pathophysiology.
DIC
HELLP
genetic
microangiopathy
pathogenesis
placenta
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
21 Feb 2022
21 Feb 2022
Historique:
received:
28
12
2021
revised:
10
02
2022
accepted:
18
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
1
3
2022
Statut:
epublish
Résumé
HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and low platelets, represents a severe pregnancy complication typically associated with hypertension. It is associated with increased risks of adverse complications for both mother and fetus. HELLP occurs in 0.2-0.8% of pregnancies, and, in 70-80% of cases, it coexists with preeclampsia (PE). Both of these conditions show a familial tendency. A woman with a history of HELLP pregnancy is at high risk for developing this entity in subsequent pregnancies. We cannot nominate a single worldwide genetic cause for the increased risk of HELLP. Combinations of multiple gene variants, each with a moderate risk, with concurrent maternal and environmental factors are thought to be the etiological mechanisms. This review highlights the significant role of understanding the underlying pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease's course supports early detection, an accurate diagnosis, and proper management of this life-threatening condition.
Identifiants
pubmed: 35208649
pii: medicina58020326
doi: 10.3390/medicina58020326
pmc: PMC8875732
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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