A Mixture of Topical Forms of Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuated Skin Pigmentation and Increased Skin Elasticity by Modulating Nuclear Factor Erythroid 2-like 2.
Ascorbic Acid
/ chemistry
Biomarkers
Elasticity
Gene Expression
Immunohistochemistry
Matrix Metalloproteinases
/ genetics
Melanins
/ biosynthesis
NF-E2-Related Factor 2
/ genetics
Niacinamide
/ administration & dosage
Polydeoxyribonucleotides
/ administration & dosage
Skin
/ drug effects
Skin Physiological Phenomena
/ drug effects
Skin Pigmentation
/ drug effects
Ultraviolet Rays
niacinamide
nuclear factor erythroid-2-related factor 2
polydeoxyribonucleotide
skin pigmentation
vitamin C
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Feb 2022
14 Feb 2022
Historique:
received:
10
01
2022
revised:
11
02
2022
accepted:
12
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
3
3
2022
Statut:
epublish
Résumé
It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloproteinases (MMPs), which degrade collagen and elastin fibers, leading to decreased skin elasticity. Various antioxidant agents, such as vitamin C and niacinamide, have been evaluated for use as treatments for photoaging or skin pigmentation. In this study, we evaluated the ability of a topical liquid formula of polydeoxyribonucleotide (PDRN), vitamin C, and niacinamide (PVN) delivered via a microneedling therapy system (MTS) to attenuate photoaging and pigmentation by increasing nuclear factor erythroid 2-like 2 (NRF2)/heme oxygenase-1 (HO-1) and decreasing MMP expression in a UV-B-radiated animal model. The effects of the PVN were compared with those of individual PDRN and hydroquinone (HQ) compounds. The expression of NRF2/HO-1 significantly increased in response to HQ, PDRN, and PVN in UV-B-radiated animal skin. The activity of nicotinamide adenine dinucleotide phosphate hydrogen oxidase decreased in response to HQ, PDRN, and PVN, and the superoxide dismutase activity increased. The expression of tumor protein p53 and microphthalmia-associated transcription factor and tyrosinase activity decreased in response to HQ, PDRN, and PVN, and this decrease was accompanied by decreased melanin content in the skin. The expression of nuclear factor kappa-light-chain enhancer of activated B cells and MMP2/3/9 decreased in response to HQ, PDRN, and PVN in UV-B-radiated skin. However, the expression of collagen type I α1 chain and the amount of collagen fibers that were evaluated by Masson's trichrome staining increased in response to HQ, PDRN, and PVN. The contents of elastin fibers, fibrillin 1/2 and fibulin 5 increased in response to HQ, PDRN, and PVN. In conclusion, PVN delivered via MTS led to decreased melanogenesis and destruction of collagen and elastin fibers by MMPs, and, thus, PVN decreased skin pigmentation and increased skin elasticity.
Identifiants
pubmed: 35209068
pii: molecules27041276
doi: 10.3390/molecules27041276
pmc: PMC8879610
pii:
doi:
Substances chimiques
Biomarkers
0
Melanins
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Polydeoxyribonucleotides
0
Niacinamide
25X51I8RD4
Matrix Metalloproteinases
EC 3.4.24.-
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : I`ll Global Inc. Co.
ID : 2021 01 290001
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