Challenges in the Use of Targeted Therapies in Non-Small Cell Lung Cancer.
Challenges
Cost
Drug resistance
Lung neoplasms
NSCLC
Non-small cell lung cancer
Targeted therapy
Journal
Cancer research and treatment
ISSN: 2005-9256
Titre abrégé: Cancer Res Treat
Pays: Korea (South)
ID NLM: 101155137
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
12
02
2022
accepted:
16
02
2022
pubmed:
26
2
2022
medline:
20
4
2022
entrez:
25
2
2022
Statut:
ppublish
Résumé
Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing amounts of identifiable oncogene drivers have led to the development of molecularly targeted drugs. Undoubtedly, the future of thoracic oncology is shifting toward increased molecular testing and the use of targeted therapies. For the most part, these novel drugs have proven to be safe and effective. As with all great innovations, targeted therapies pose unique challenges. Drug toxicities, resistance, access, and costs are some of the expected obstacles that will need to be addressed. This review highlights some of the major challenges in the use of targeted therapies in NSCLC and provides guidance for the future strategies.
Identifiants
pubmed: 35209703
pii: crt.2022.078
doi: 10.4143/crt.2022.078
pmc: PMC9016301
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
315-329Références
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