Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates:

Animals Brain / diagnostic imaging Macaca mulatta / metabolism Positron-Emission Tomography / methods Radiopharmaceuticals / metabolism Receptors, N-Methyl-D-Aspartate / metabolism
(R)-[11C]NR2B-Me (R)-[18F]OF-Me-NB1 (S)-[18F]OF-NB1 GluN2B subunit NMDA receptor Positron emission tomography glutamate

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
08 2022
Historique:
pubmed: 26 2 2022
medline: 9 7 2022
entrez: 25 2 2022
Statut: ppublish

Résumé

The NMDA receptor GluN2B subunit is a target of interest in neuropsychiatric disorders but to date there is no selective radiotracer available to quantify its availability

Identifiants

DOI: 10.1177/0271678X221084416 PMID: 35209743 PMC: PMC9274863
pubmed: 35209743
doi: 10.1177/0271678X221084416
pmc: PMC9274863
doi:

Substances chimiques

Radiopharmaceuticals 0
Receptors, N-Methyl-D-Aspartate 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1398-1409

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIH HHS
ID : S10 OD018034
Pays : United States
Organisme : NIH HHS
ID : S10 OD019967
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH107803
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 MH002795
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 MH002793
Pays : United States

Références

Eur J Med Chem. 2020 Aug 15;200:112447
pubmed: 32450321
J Nucl Med. 2020 Aug;61(8):1212-1220
pubmed: 31924728
J Gen Physiol. 2018 Aug 6;150(8):1081-1105
pubmed: 30037851
J Med Chem. 2012 Oct 11;55(19):8272-8282
pubmed: 22853801
J Cereb Blood Flow Metab. 2020 Sep;40(9):1769-1777
pubmed: 32663096
Magn Reson Imaging. 2017 Nov;43:144-150
pubmed: 28755862
Pharmacol Rev. 2018 Jul;70(3):621-660
pubmed: 29945898
Neurochem Int. 2012 Jan;60(2):170-6
pubmed: 22197911
J Cereb Blood Flow Metab. 2014 Jul;34(7):1162-8
pubmed: 24736889
Mol Cell Neurosci. 2011 Dec;48(4):308-20
pubmed: 21600287
J Nucl Med. 2021 Feb;62(2):259-265
pubmed: 32737247
J Med Chem. 1999 Jul 29;42(15):2993-3000
pubmed: 10425109
Molecules. 2020 Oct 16;25(20):
pubmed: 33081223
J Nucl Med. 2022 Jun;63(6):936-941
pubmed: 34620732
Nat Rev Neurosci. 2013 Jun;14(6):383-400
pubmed: 23686171
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130163
pubmed: 24298164
Arch Gen Psychiatry. 2006 Aug;63(8):856-64
pubmed: 16894061
Expert Opin Ther Pat. 2020 Oct;30(10):743-767
pubmed: 32926646
Neuron. 2019 Mar 6;101(5):774-778
pubmed: 30844397
Appl Radiat Isot. 2001 Feb;54(2):203-8
pubmed: 11200881
J Nucl Med. 2018 Apr;59(4):698-703
pubmed: 29191857
J Cereb Blood Flow Metab. 2010 Jan;30(1):46-50
pubmed: 19738632
J Med Chem. 2019 Nov 14;62(21):9450-9470
pubmed: 31657559
J Cereb Blood Flow Metab. 2002 Oct;22(10):1271-81
pubmed: 12368666
Acta Pharmacol Sin. 2021 Mar;42(3):491-498
pubmed: 32661351
Mol Pharmacol. 2012 Aug;82(2):344-59
pubmed: 22596351
J Nucl Med. 2019 Aug;60(8):1167-1173
pubmed: 30683765
Nature. 2012 Sep 20;489(7416):391-399
pubmed: 22996553
Neuron. 1994 Mar;12(3):529-40
pubmed: 7512349
Science. 2002 Oct 25;298(5594):846-50
pubmed: 12399596
J Nucl Med. 2018 Jul 20;:
pubmed: 30030340
Neuroreport. 1992 Dec;3(12):1138-40
pubmed: 1493227
Nature. 1999 Sep 2;401(6748):63-9
pubmed: 10485705
Nucl Med Biol. 2000 Oct;27(7):657-60
pubmed: 11091108
Mol Neurobiol. 2021 Jul;58(7):3443-3456
pubmed: 33723767
J Neurosci. 2014 Aug 20;34(34):11325-38
pubmed: 25143613
Arch Gen Psychiatry. 1994 Mar;51(3):199-214
pubmed: 8122957
J Neurosci. 2002 May 1;22(9):3628-37
pubmed: 11978838
Biol Psychiatry. 2012 Aug 15;72(4):331-8
pubmed: 22516044
Neuropharmacology. 2014 Nov;86:174-80
pubmed: 25063581
Nucl Med Biol. 2000 Aug;27(6):627-30
pubmed: 11056380

Auteurs

Kelly Smart (K)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.

Ming-Qiang Zheng (MQ)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.

Hazem Ahmed (H)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.
Institute of Pharmaceutical Sciences, Zurich, Switzerland.

Hanyi Fang (H)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.
Union Hospital, Huazhong University of Science and Technology, Wuhan, China.

Yuping Xu (Y)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.
Jiangsu Institute of Nuclear Medicine, Jiangsu, China.

Lisheng Cai (L)

Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA.

Daniel Holden (D)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.

Michael Kapinos (M)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.

Ahmed Haider (A)

Institute of Pharmaceutical Sciences, Zurich, Switzerland.

Zachary Felchner (Z)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.

Jim R Ropchan (JR)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.

Gilles Tamagnan (G)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.

Robert B Innis (RB)

Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA.

Victor W Pike (VW)

Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA.

Simon M Ametamey (SM)

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.

Yiyun Huang (Y)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.

Richard E Carson (RE)

Yale School of Medicine, Yale PET Center, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Comparison of three novel radiotracers for...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Comparison of three novel radiotracers for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Comparison of three novel radiotracers for...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Comparison of three novel radiotracers for...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Comparison of three novel radiotracers for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs du N-méthyl-D-aspartate › Comparison of three novel radiotracers for...