Correlation Between Inflammatory and Biochemical Parameters in Patients with Diabetes and Urinary Tract Infection.
Diabetes mellitus
hyperglycemia
urinary tract infection
Journal
Materia socio-medica
ISSN: 1512-7680
Titre abrégé: Mater Sociomed
Pays: Bosnia and Herzegovina
ID NLM: 101281595
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
12
11
2021
accepted:
24
12
2021
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
ppublish
Résumé
Hyperglycemia, polyuria, and glycosuria are all risk factors for the frequency of urinary tract infections in patients with diabetes. The aim of this study is to establish correlation between inflammatory and biochemical parameters in patients with diabetes and urinary tract infection. Total number 116 patients were monitored, at the ages between 18-95 years, with diabetes and urinary tract infection, of which 59.49% women and 40.51% men. Patients were with a duration of diabetes from 0 to over 20 years, with an average fasting glycemia of 9.54 mmol/l, and postprandial glycemia 13.94 mmol/l, HbA1C 9.92%, which have been poorly regulated in the last 3-4 months. Inflammatory parameters SE, CRP, leukocytes were correlated with inflammatory parameters of urine sediment and positive urine cultures. Average values of urea, creatinine, and proteinuria were positively correlated with the duration of diabetes. Escherichia coli, Enterococcus feecalis, and Candida albicans were the most common pathogens isolated in urine culture, 51 patients had reinfection once, 39 patients had two reinfections, and 26 patients had three reinfections during the 6-month follow-up. Duration of diabetes, long-term poor glycoregulation lead to microangiopathic changes in the kidneys in the form of diabetic nephropathy with retention of nitrogenous substances of urea, creatinine with proteinuria, and acute hyperglycemia, polyuria and glycosuria, further leading to frequent urinary tract infections.
Sections du résumé
BACKGROUND
BACKGROUND
Hyperglycemia, polyuria, and glycosuria are all risk factors for the frequency of urinary tract infections in patients with diabetes.
OBJECTIVE
OBJECTIVE
The aim of this study is to establish correlation between inflammatory and biochemical parameters in patients with diabetes and urinary tract infection.
METHODS
METHODS
Total number 116 patients were monitored, at the ages between 18-95 years, with diabetes and urinary tract infection, of which 59.49% women and 40.51% men. Patients were with a duration of diabetes from 0 to over 20 years, with an average fasting glycemia of 9.54 mmol/l, and postprandial glycemia 13.94 mmol/l, HbA1C 9.92%, which have been poorly regulated in the last 3-4 months. Inflammatory parameters SE, CRP, leukocytes were correlated with inflammatory parameters of urine sediment and positive urine cultures.
RESULTS
RESULTS
Average values of urea, creatinine, and proteinuria were positively correlated with the duration of diabetes. Escherichia coli, Enterococcus feecalis, and Candida albicans were the most common pathogens isolated in urine culture, 51 patients had reinfection once, 39 patients had two reinfections, and 26 patients had three reinfections during the 6-month follow-up.
CONCLUSION
CONCLUSIONS
Duration of diabetes, long-term poor glycoregulation lead to microangiopathic changes in the kidneys in the form of diabetic nephropathy with retention of nitrogenous substances of urea, creatinine with proteinuria, and acute hyperglycemia, polyuria and glycosuria, further leading to frequent urinary tract infections.
Identifiants
pubmed: 35210944
doi: 10.5455/msm.2021.33.240-243
pii: MSM-33-240
pmc: PMC8812372
doi:
Types de publication
Journal Article
Langues
eng
Pagination
240-243Informations de copyright
© 2021 Azra Burekovic, Edhem Haskovic, Faruk Ceric, Dzenana Halilovic.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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