Inteins as Drug Targets and Therapeutic Tools.
anti-microbial
drug target
inhibitor
intein
therapeutic tool
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
11
2021
accepted:
10
01
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Multidrug-resistant pathogens are of significant concern in recent years. Hence new antifungal and anti-bacterial drug targets are urgently needed before the situation goes beyond control. Inteins are polypeptides that self-splice from exteins without the need for cofactors or external energy, resulting in joining of extein fragments. Inteins are present in many organisms, including human pathogens such as
Identifiants
pubmed: 35211511
doi: 10.3389/fmolb.2022.821146
pii: 821146
pmc: PMC8861304
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
821146Subventions
Organisme : NIAID NIH HHS
ID : R01 AI140726
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI161845
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI140406
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131669
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI141178
Pays : United States
Informations de copyright
Copyright © 2022 Tharappel, Li and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Biol Chem. 2014 May 23;289(21):14490-7
pubmed: 24695741
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3410-5
pubmed: 8622949
PLoS Pathog. 2021 Mar 12;17(3):e1009439
pubmed: 33711082
Fungal Genet Biol. 2005 May;42(5):452-63
pubmed: 15809009
Mycoses. 2017 May;60(5):296-309
pubmed: 28176377
Science. 2007 Oct 19;318(5849):459-63
pubmed: 17947583
J Bacteriol. 2008 Sep;190(17):5934-43
pubmed: 18606739
Nat Commun. 2020 Jan 8;11(1):127
pubmed: 31913284
PLoS One. 2013 May 09;8(5):e63128
pubmed: 23671662
PLoS Biol. 2019 Oct 10;17(10):e3000104
pubmed: 31600193
FEBS J. 2020 May;287(9):1886-1898
pubmed: 31665813
Nat Struct Biol. 1998 Jan;5(1):31-6
pubmed: 9437427
Mycopathologia. 2020 Feb;185(1):37-49
pubmed: 31286362
J Bacteriol. 2011 Apr;193(8):2035-41
pubmed: 21317331
Gene. 1989 Oct 30;82(2):313-5
pubmed: 2684784
J Biol Chem. 2009 Sep 18;284(38):25912-28
pubmed: 19605345
Nat Rev Drug Discov. 2021 Apr;20(4):309-325
pubmed: 33536635
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9226-31
pubmed: 9689062
Front Microbiol. 2016 Oct 10;7:1585
pubmed: 27777569
Nat Commun. 2020 Mar 23;11(1):1529
pubmed: 32251274
Cell Mol Life Sci. 2013 Apr;70(7):1185-206
pubmed: 22926412
J Biol Chem. 2010 Jan 22;285(4):2515-26
pubmed: 19940146
Infect Control Hosp Epidemiol. 2019 Dec;40(12):1442-1444
pubmed: 31566144
FEBS Lett. 2004 Aug 13;572(1-3):46-50
pubmed: 15304322
Med Mycol Case Rep. 2019 Dec 03;27:1-3
pubmed: 31867171
Sci Transl Med. 2019 May 15;11(492):
pubmed: 31092694
Biotechnol Lett. 2015 Nov;37(11):2121-37
pubmed: 26153348
Mol Ther. 2020 Apr 8;28(4):1177-1189
pubmed: 31991108
Sci China Life Sci. 2010 Jun;53(6):683-9
pubmed: 20602271
Int Immunopharmacol. 2019 Jan;66:288-295
pubmed: 30502650
Front Med (Lausanne). 2021 Apr 23;8:670731
pubmed: 33968970
Mol Microbiol. 2003 Dec;50(5):1569-77
pubmed: 14651639
Mycopathologia. 2020 Feb;185(1):1-8
pubmed: 32002816
Nat Biotechnol. 2019 Jul;37(7):755-760
pubmed: 30988505
Front Biosci. 2003 Sep 01;8:s1157-65
pubmed: 12957838
Microbiol Spectr. 2021 Oct 31;9(2):e0030121
pubmed: 34549994
J Biol Chem. 2014 May 23;289(21):14498-505
pubmed: 24695729
Microorganisms. 2020 Dec 16;8(12):
pubmed: 33339089
PLoS Pathog. 2019 Sep 19;15(9):e1007977
pubmed: 31536607
Biochimie. 2021 Jun;185:53-67
pubmed: 33727137
Genome Res. 1997 Aug;7(8):802-19
pubmed: 9267804
J Biol Chem. 2016 Oct 21;291(43):22661-22670
pubmed: 27609519
Mol Biol Evol. 2016 Mar;33(3):783-99
pubmed: 26609079
Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22164-22172
pubmed: 31611397
Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):
pubmed: 33397721
J Bacteriol. 2006 May;188(9):3412-4
pubmed: 16621837
BMC Evol Biol. 2006 May 31;6:42
pubmed: 16737526
Front Microbiol. 2020 Aug 13;11:1895
pubmed: 32903830
Lancet Infect Dis. 2010 Feb;10(2):103-11
pubmed: 20113979
Mol Endocrinol. 1988 Apr;2(4):307-12
pubmed: 3380103
Nat Rev Drug Discov. 2020 Dec;19(12):839-859
pubmed: 33077937
mBio. 2020 Jul 14;11(4):
pubmed: 32665276
J Am Chem Soc. 2002 Aug 7;124(31):9044-5
pubmed: 12148996
mSphere. 2020 Apr 8;5(2):
pubmed: 32269156
Nat Commun. 2018 Oct 19;9(1):4363
pubmed: 30341292
Commun Biol. 2020 May 7;3(1):216
pubmed: 32382148
Cell. 1991 Jan 11;64(1):13-5
pubmed: 1986863
Vector Borne Zoonotic Dis. 2021 Apr;21(4):264-268
pubmed: 33434106
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10348-53
pubmed: 26240361
Nucleic Acids Res. 2015 Jul 27;43(13):6450-8
pubmed: 26082496
Curr Res Microb Sci. 2021 Jul 07;2:100047
pubmed: 34841338
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13638-43
pubmed: 10570125
J Biol Chem. 2011 Jan 14;286(2):1277-82
pubmed: 21059649
J Fungi (Basel). 2020 Feb 25;6(1):
pubmed: 32106450
Mol Microbiol. 1998 Nov;30(3):525-34
pubmed: 9822818
Chin Med J (Engl). 2019 May 20;132(10):1135-1138
pubmed: 30973451
PLoS One. 2011;6(10):e26361
pubmed: 22028863
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5455-60
pubmed: 12704232
J Biol Chem. 1990 Apr 25;265(12):6726-33
pubmed: 2139027
Nat Biomed Eng. 2020 Jan;4(1):97-110
pubmed: 31937940
J Am Chem Soc. 2009 Oct 14;131(40):14196-7
pubmed: 19807176
Biochim Biophys Acta. 2011 Dec;1814(12):1802-11
pubmed: 22001565
Chem Commun (Camb). 2013 Feb 11;49(12):1226-8
pubmed: 23288105
J Clin Microbiol. 2002 Mar;40(3):943-50
pubmed: 11880421
J Bacteriol. 1997 Oct;179(20):6378-82
pubmed: 9335286
RNA. 2005 May;11(5):533-57
pubmed: 15840809
Curr Opin Chem Biol. 2017 Jun;38:30-35
pubmed: 28258013
Hum Gene Ther. 2008 Sep;19(9):958-64
pubmed: 18788906
J Biol Chem. 2001 Apr 6;276(14):10832-8
pubmed: 11152694
PLoS One. 2013 Apr 08;8(4):e59516
pubmed: 23593141
EMBO J. 1994 Feb 1;13(3):699-703
pubmed: 7508863
J Fungi (Basel). 2020 Nov 27;6(4):
pubmed: 33261213
Emerg Microbes Infect. 2019;8(1):895-908
pubmed: 31223062
Mol Ther Methods Clin Dev. 2021 Oct 19;23:448-459
pubmed: 34786437
Lancet. 2019 Apr 20;393(10181):1642-1656
pubmed: 30904262
Infect Genet Evol. 2013 Aug;18:174-82
pubmed: 23665464
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10505-10
pubmed: 15247421
Protein Sci. 1999 Mar;8(3):644-53
pubmed: 10091667
Nucleic Acids Res. 2001 Sep 15;29(18):3757-74
pubmed: 11557808
J Biol Chem. 1986 Apr 5;261(10):4738-48
pubmed: 3007474
Fungal Genet Biol. 2011 Feb;48(2):80-91
pubmed: 20682355
Anal Biochem. 2015 Nov 1;488:1-5
pubmed: 26095399
Chem Sci. 2014;5(1):446-461
pubmed: 24634716
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22090-22100
pubmed: 32839344
Cell. 1997 Oct 3;91(1):85-97
pubmed: 9335337
Mol Cell. 2018 Jun 7;70(5):768-784
pubmed: 29398446
Ther Clin Risk Manag. 2014 Feb 13;10:95-105
pubmed: 24611015
Chemistry. 2010 Apr 12;16(14):4297-306
pubmed: 20209535
Cell. 1998 Jan 9;92(1):1-4
pubmed: 9489693
J Antibiot (Tokyo). 2018 Nov;71(12):978-991
pubmed: 30242283
Cell. 1987 Jul 31;50(3):509-17
pubmed: 3607877
Chem Biol. 2011 May 27;18(5):619-30
pubmed: 21609843
Mol Microbiol. 1993 Jan;7(2):197-206
pubmed: 8446027
J Biol Chem. 2015 May 1;290(18):11591-600
pubmed: 25787080
Sci Rep. 2020 May 8;10(1):7769
pubmed: 32385378