Clinical characteristics of children and adolescents with ADHD with or without methylphenidate prescription at their first diagnostic assessment.
ADHD
Early intervention
Methylphenidate
Psychopathology
Treatment predictors
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
14
06
2021
accepted:
01
02
2022
pubmed:
26
2
2022
medline:
16
11
2022
entrez:
25
2
2022
Statut:
ppublish
Résumé
Attention Deficit/Hyperactivity Disorder (ADHD) is the most prevalent neurodevelopmental disorder diagnosed in the scholar age. It is associated with significant impairment in global functioning, and in moderate/severe presentations the outcome is critically dependent on pharmacological optimization of the multi-modal treatment. Methylphenidate (MPH) is the first-choice pharmacological treatment in children and adolescents with ADHD, with substantial evidence of significant efficacy and effectiveness on global functioning and symptoms' severity. There is some evidence supporting a few clinical and socio-demographic variables as predictors of pharmacological treatment prescription in children with ADHD independently of ADHD symptoms severity. However, it is warranted to investigate clinical and general psychopathological characteristics potentially associated with negative outcomes and the need for pharmacological treatment to inform appropriate prescription strategies. In this context, we compared 268 children and adolescents who were prescribed MPH (ADHD/MPH) for the first time after their first diagnostic assessment at our center, and 444 children and adolescents with ADHD (ADHD/noMPH) who were recommended non-pharmacological evidence-based interventions alone. ADHD/MPH group had higher severity of non-ADHD psychopathological symptoms compared to the ADHD/noMPH group, as documented by higher scores on the Child Behavior Checklist (CBCL) subscales, higher severity of ADHD symptoms, lower average IQ and lower adaptive levels independently of IQ. More specifically, beside externalizing symptoms, also internalizing symptoms were significantly higher in the ADHD/MPH group. The presence of significant non-ADHD psychopathology should be considered as a clinical factor associated with the need for MPH prescription in children and adolescents with ADHD.
Identifiants
pubmed: 35211779
doi: 10.1007/s00406-022-01386-9
pii: 10.1007/s00406-022-01386-9
doi:
Substances chimiques
Methylphenidate
207ZZ9QZ49
Central Nervous System Stimulants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1437-1442Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
Références
Polanczyk G, de Lima MS, Horta BL et al (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164:942–948
doi: 10.1176/ajp.2007.164.6.942
pubmed: 17541055
Polanczyk GV, Willcutt EG, Salum GA et al (2014) ADHD prevalence estimates across three decades: An updated systematic review and meta-regression analysis. Int J Epidemiol 43:434–442
doi: 10.1093/ije/dyt261
pubmed: 24464188
pmcid: 4817588
Donfrancesco R, Marano A, Calderoni D et al (2015) Prevalence of severe ADHD: an epidemiological study in the Italian regions of Tuscany and Latium. Epidemiol Psychiatr Sci 24:525–533
doi: 10.1017/S2045796014000523
pubmed: 25221947
Arnold LE, Hodgkins P, Caci H et al (2015) Effect of treatment modality on long-term outcomes in attention-deficit/hyperactivity disorder: A systematic review. PLoS ONE 10(2):e0116407
doi: 10.1371/journal.pone.0116407
pubmed: 25714373
pmcid: 4340791
Cortese S, Adamo N, Del Giovane C et al (2018) Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry 5(9):727–738
doi: 10.1016/S2215-0366(18)30269-4
pubmed: 30097390
pmcid: 6109107
Leucht S, Helfer B, Gartlehner G, Davis JM (2015) How effective are common medications: a perspective based on meta-analyses of major drugs. BMC Med 13:253
doi: 10.1186/s12916-015-0494-1
pubmed: 26431961
pmcid: 4592565
Casadei G, Cartabia M, Reale L et al (2017) Italian regional health service costs for diagnosis and 1-year treatment of ADHD in children and adolescents. Int J Ment Health Syst 11:33
doi: 10.1186/s13033-017-0140-8
pubmed: 28465719
pmcid: 5410029
Germinario AEP, Arcieri R, Marzi M, et al (2016) ADHD (Attention-Deficit/Hyperactivity Disorder) National Register (Italy): data 2007–2016. 34 p. Rapporti ISTISAN 16/37 (in Italian)
Russell AE, Ford T, Russell G (2019) Barriers and predictors of medication use for childhood ADHD: findings from a UK population-representative cohort. Soc Psychiatry Psychiatr Epidemiol 54:1555–1564
doi: 10.1007/s00127-019-01720-y
pubmed: 31073627
pmcid: 6858474
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (5th ed.) https://doi.org/10.1176/appi.books.9780890425596
Kaufman J, Birmaher B, Brent D et al (1997) Schedule for affective disorders and schizophrenia for school-age children present and lifetime version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988
doi: 10.1097/00004583-199707000-00021
pubmed: 9204677
National Institute for Health and Care Excellence (2018) Attention deficit hyperactivity disorder: diagnosis and management. https://www.nice.org.uk/guidance/ng87
Shaffer D, Gould MS, Brasic J et al (1983) A children’s global assessment scale (CGAS). Arch Gen Psychiatry 40:1228–1231
doi: 10.1001/archpsyc.1983.01790100074010
pubmed: 6639293
Grizzle R (2011) Wechsler Intelligence Scale for Children, Fourth Edition. In: Goldstein S, Naglieri JA (eds) Encyclopedia of Child Behavior and Development. Springer, US, Boston, MA, pp 1553–1555
doi: 10.1007/978-0-387-79061-9_3066
Raven J (1981) Manual for Raven’s Progressive Matrices and Vocabulary Scales. Research Supplement No.1: The 1979 British Standardisation of the Standard Progressive Matrices and Mill Hill Vocabulary Scales, Together With Comparative Data From Earlier Studies in the UK, San Antonio, Texas
Oakland T (2011) Adaptive Behavior Assessment System – Second Edition BT - Encyclopedia of Clinical Neuropsychology. In: Kreutzer JS, DeLuca J, Caplan B (eds) Springer. New York, NY, New York, pp 37–39
Sparrow SS (2011) Vineland Adaptive Behavior Scales BT - Encyclopedia of Clinical Neuropsychology. In: Kreutzer JS, DeLuca J, Caplan B (eds) Springer. New York, NY, New York, pp 2618–2621
Conners CK, Sitarenios G, Parker JDA, Epstein JN (1998) the revised conners’ parent rating scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:257–268
doi: 10.1023/A:1022602400621
pubmed: 9700518
Volkmar FR (2013) Child Behavior Checklist for Ages 6–18 BT - Encyclopedia of Autism Spectrum Disorders. Springer New York, New York, NY, p 581
Katsuki D, Yamashita H, Yamane K et al (2020) Clinical subtypes in children with attention-deficit hyperactivity disorder according to their child behavior checklist profile. Child Psychiatry Hum Dev 51(6):969–977
doi: 10.1007/s10578-020-00977-8
pubmed: 32166459
Frazier TW, Demaree HA, Youngstrom EA (2004) Meta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder. Neuropsychology 18(3):543–555
doi: 10.1037/0894-4105.18.3.543
pubmed: 15291732
Katusic MZ, Voigt RG, Colligan RC et al (2011) Attention-deficit hyperactivity disorder in children with high intelligence quotient: Results from a population-based study. J Dev Behav Pediatr 32(2):103–109
doi: 10.1097/DBP.0b013e318206d700
pubmed: 21200330
pmcid: 3095845
Mahone EM, Hagelthorn KM, Cutting LE et al (2002) Effects of IQ on executive function measures in children with ADHD. Child Neuropsychol 8(1):52–65
doi: 10.1076/chin.8.1.52.8719
pubmed: 12610776
He XX, Qian Y, Wang YF (2013) Practical executive function performance in high intelligence quotient children and adolescents with attention-deficit/hyperactivity disorder. Natl Med J China 93(3):172–176
Daviss WB (2008) A review of co-morbid depression in pediatric ADHD: Etiology, phenomenology, and treatment. J Child Adolesc Psychopharmacol 18(6):565–571
doi: 10.1089/cap.2008.032
pubmed: 19108661
pmcid: 2699665
Mannuzza S, Klein RG, Moulton JL 3rd (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatry Res 160:237–246
doi: 10.1016/j.psychres.2007.11.003
pubmed: 18707766
pmcid: 2581455
Shaw M, Hodgkins P, Caci H et al (2012) A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: Effects of treatment and non-treatment. BMC Med 10:99
doi: 10.1186/1741-7015-10-99
pubmed: 22947230
pmcid: 3520745
Frazzetto G, Keenan S, Singh I (2007) ‘I Bambini e le Droghe’: The Right to Ritalin vs the Right to Childhood in Italy. BioSocieties 2(4):393–412
doi: 10.1017/S1745855207005844
Biederman J, DiSalvo M, Vaudreuil C et al (2020) Can the Child Behavior Checklist (CBCL) help characterize the types of psychopathologic conditions driving child psychiatry referrals? Scand J Child Adolesc Psychiatry Psychol 8:157–165